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CODA day! The CODA team at Johns Hopkins University maps pancreatic precursor lesions in 3D and at single-cell level. First 3D spatial genomic maps of large tissue samples. A human pancreas contains a staggering ~1000 lesions, some showing multifocality. Here: nature.com/articles/s4158…

Do you check pancreatic neck margin for frozen section in post-neoadjuvant PD❓In our new paper with Ospedale San Raffaele + Mass General Surgery, conversion of an initially positive neck margin by additional resection was not associated with improved outcomes. journals.lww.com/annalsofsurger…

Thrilled to have presented at the Surgical Infection Society the BIOSTEPS trial, evaluating the efficacy of the first antimicrobial stewardship program dedicated to pancreatic surgery. Tailored antibiotic prophylaxis and rectal swab are the keys to reducing SSI! Pancreas Verona Heather Evans MD, MS, FACS, FSIS

Giovanni Marchegiani Mauro Podda BJS Open Ville Sallinen Des Winter BJS Academy Nik Machairas Young BJS Julio Mayol Jeff Matthews MD Kjetil Søreide Pip/Tazo is in the World Health Organization (WHO) Watch category of the AWaRe classification and it should not be used deliberately! It’s a lazy way of treating SSI. More appropriate to tailor the treatment based on bile stenting, preop bile culture, and rectal swab colonization with MDR! Heather Evans MD, MS, FACS, FSIS

Please help us with this brief survey for HPB surgeons/trainees: E-AHPBA Survey on Training for Fellows docs.google.com/forms/d/e/1FAI… Feel free to share this survey with colleagues! E-AHPBA European Society of Surgical Oncology (ESSO) IHPBA SoMe4HPB Karolinska-HPB Marc Besselink UEMS Section of Surgery @dr_gilgson

Now in Modern Pathology our paper on intraductal oncocytic papillary neoplasm (IOPN) of the pancreas. It is a distinct entity among pancreatic neoplasms, with specific histological, IHC, and molecular features. And important clinical implications. modernpathology.org/article/S0893-…

This is an important multi institutional dataset on intraductal papillary mucinous neoplasms (IPMNs), the most common cystic precursor lesion of #PancreaticCancer. Precursor Epithelial Subtypes of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasms (A-IPMN):

🚨The MetroPancreas model can help predict a futile upfront resection for PDAC (death or recurrence within 6mo) and select parients for neoadjuvant strategies using simple clinical parameters. Check it out ➡️ jamanetwork.com/journals/jamas… Online calculator ➡️ aicep.website/metropancreas/

New preprint from Prof David K. Chang Nigel B. Jamieson & colleagues Clonal evolutionary analysis reveals patterns of malignant transformation in #PancreaticCancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN) biorxiv.org/content/10.110… Phylogenetic analysis identifies two distinct

Buckle up guys… 13-15% global prevalence of IPMN.. 🍇 👉🏻 Global Prevalence of Pancreatic Cystic Lesions in the General Population on Magnetic Resonance Imaging: A Systematic Review and Meta-analysis ⁦Giovanni Marchegiani⁩ cghjournal.org/article/S1542-…

Pancreatic cysts are often found incidentally on imaging tests for other indications. Imaging, symptom assessment, and laboratory tests can help distinguish benign cysts from those associated with a risk of malignant transformation. Learn more: nej.md/4g4jz5s

🚨 #PRODIGE44 - preop radiation for LA-BR-PDAC Phase 2 of👥110 pts Preop mFOLFIRINOX + rads🆚no rads ❌No difference R0 ❌No difference OS or PFS #ESMO24 really hitting nail in⚰️of neoadj rads in GI cancers 🎉Great news: close 50 months median OS with resection after NAT!

Neoadjuvant therapy versus upfront surgery in resectable pancreatic cancer: reconstructed patient-level meta-analysis of randomized clinical trials ➡️doi.org/10.1093/bjsope… This study aimed to assess the impact of neoadjuvant treatment compared with upfront surgery on the

Comprehensive pathologic review of post-neoadjuvant pancreatectomy specimens identified 10 morphologic subtypes, which correlate with survival. Also, intratumor spatial heterogeneity is associated with bad prognosis.

It’s time to find the 4th person for our international clinical and research HPB fellowship Karolinska-HPB starting September 2025! Please apply before January 6. Previous fellows Giampaolo Perri & @TimTransplant have been excellent & current fellow @Martina_Nebbia is great!

Thank you Ernesto Sparrelid @dr_gilgson and Karolinska-HPB for the incredible opportunity to collaborate and learn in such an inspiring environment! Grateful to Pancreas Verona for supporting this exchange. Here’s to building bridges and shaping the future together! 🌍🚀

New paper on spatial transcriptomics (using GeoMx and CosMx platforms) of Intraductal Papillary Mucinous Neoplasms (IPMNs), precursor lesions of #PancreaticCancer. BY Yasmin Hernandez-Barco, MD & colleagues MassGeneral News This study identifies the transcriptomic features of

A 4-year program has boosted MIS from 15% to 41% at Karolinska Univ.sjuk ! Training young generation of surgeons is the key for a proficient, self-sustainable robotic program🦾 Thanks to Ernesto Sparrelid and StefanGilg for supporting and mentoring me!

Nature research paper: Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer go.nature.com/4jHJAJv

Anatomically resectable versus biologically borderline resectable pancreatic cancer definition: refining the border beyond anatomical criteria and biological aggressiveness ➡️doi.org/10.1093/bjsope… Patients with biologically borderline resectable pancreatic cancer—an