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Thrilled to share our work on novo protein LYTAC(pLYTAC)/EndoTag in @nature! Using de novo protein design, we created endocytosis triggering binding proteins (EndoTags) to degrade extracellular targets and amplify receptor signaling. nature.com/articles/s4158…

Congratulations to the entire Xin Zhou Lab in collaboration with the Pasi lab on this new manuscript! Thank you Xin for letting me support this incredible project. Honored and grateful to have been a part it! #SiSePuede

Transferrin receptor targeting chimeras for membrane protein degradation nature.com/articles/s4158…

Photoproximity profiling of native integrin “social networks” on cancer cells/tissues. We’ve long been fascinated by these important and dynamic adhesion receptors and how they do their job and who they do it with. No Abs or genetic constructs needed! biorxiv.org/content/10.110…

We are excited to share our lab’s first research article! rdcu.be/dU5AC We have developed Transferrin Receptor Targeting Chimeras (TransTACs), a novel class of heterobispecific antibodies designed for targeted degradation of membrane proteins. nature.com/articles/s4158…

Flight + Fight. Presenting the @OregonFootball Heroes Uniform. Designed by the Lanning family, each thread represents triumph – showing support for those who have battled cancer + raising awareness as we fight for the cure. #StompOutCancer

I am incredibly excited to chair the faculty search this year. This community is an incredible place to start a lab and I’m proud to be a colleague to our many outstanding investigators. Feel free to ask me any questions on the search!

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Published today! Spatial proteomics reveals JAK/STAT as a target for Toxic Epidermal Necrolysis, an often fatal skin reaction to common medication. We validated our findings in pre-clinical models & successfully treated the first patients worldwide.🧵⬇️ nature.com/articles/s4158…

Thanks to the ECR committee and #HUPO2024 for this honor! 🥂🎉🥳Also, huge congrats to the people who did the work, especially Joann Chongsaritsinsuk, Alexandra Steigmeyer, Keira E Mahoney, mia! #glycotime #TeamMassSpec Check out the “highlight of the year” here: nature.com/articles/s4146…

Harvard has set an example for other higher-ed institutions – rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking concrete steps to make sure all students at Harvard can benefit from an environment of intellectual inquiry, rigorous debate and

Making cryo-EM grids by flying particles through a native mass-spec is pretty cool, but can it be cooler? Yes - by adding a LASER! Particles damaged by the process can be fixed by adding a thin layer of ice then briefly hitting the grid with a laser! tinyurl.com/49aurm35

My lab is recruiting a postdoc fellow to characterize new biochemical pathways that control taurine and glucose metabolism. Email me at [email protected] to apply! Please help RT🙏 Long Lab Judith Simcox PhD UW–Madison Biochem

The W-S lab is seeking to hire a research scientist! This person will lead wet-lab innovations in our team as we combine AI and experiments to understand and design dynamics! Thanks for sharing/RTs! jobs.wisc.edu/jobs/scientist…

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…

I had a blast last week attending my first ASMS as a postdoc! I feel so fortunate for this mass spec community as we champion open and accessible science.

Happy to have contributed in a small way to this very cool study from Jim Wells lab, led by Fangzhu Zhao. They developed low-density lipoprotein receptor-targeting chimeras (LIPTACs) to promote induced extracellular protein degradation & ADC delivery. 👏 biorxiv.org/content/10.110…

Feeling incredibly grateful to have received an NOA from the NIH National Cancer Institute to fund my F32 postdoctoral fellowship! Excited to continue exploring. #NIH #NCI #F32 #postdoc #cancerresearch