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Genomics for the Colorectal Cancer MDT 2024 - we have arrived! ⁦St Mark's Hospital Foundation⁩ ⁦LynchSyndrome_Polyposis@StMarks⁩ ⁦St Marks BCSC⁩ ⁦St Mark's Hospital⁩ ⁦North Thames Genomic Medicine Service⁩ eventbrite.co.uk/e/genomics-for…

Want to sequence the TCR repertoire in degraded or FFPE samples? Our new FUME-TCRseq method makes it easy (and cheap!). Led by the amazing Annie Baker The ICR Centre for Evolution and Cancer, ICR together with Benny Chain IIT. aacrjournals.org/cancerres/arti… Cancer Research

Chatted to Prof Sir Mel Greaves tonight at an event, one of The ICR ‘s most celebrated scientists & a world leader in childhood leukemia research This man is amazing & I can’t believe more people in UK/world don’t know about his work or the work of The ICR Short 🧵

Delighted to share our new work in Nature Cancer in collaboration with Schofield Group led by Hannah Lawson & James Holt-Martyn. We found that HIF hydroxylases are potent therapeutic targets in AML. The ICR. nature.com/articles/s4301…. 1/4

It's out! We report 3D mapping of human pancreatic precancer and associated genetic alterations. With the brilliant Ashley Kiemen and Denis Wirtz . Tweetorial to follow soon. nature.com/articles/s4158…

Pleased to present latest lab preprint showing how pathological disruption of intestinal BMP gradients gives rise to ectopic stem cell niches through stromal remodelling. biorxiv.org/cgi/content/sh…

the high incidence of pancreatic cancer precursors (PanINs) in apparently normal pancreas is just so remarkable... really fantastic work from Laura DeLong Wood and her team

"Tempora mutantur, et nos mutamur in illis". Ovid knew long ago that our somatic genomes evolve throughout life... Super excited to share our new paper on connecting clonal outgrowth in somatic evolution with epigenetic profiles nature Open here: rdcu.be/dHkeS 🪡

[t.ly/vYqW7] Cancer biomarker discovery is historically mutation-centric, often neglecting the key role of genomics instability. Recently, we asked ourselves how do mutations and copy number alterations (CNAs) determine prognosis and tropism? 😋😋1/n

I'm really pleased to announce the publication of our spatial computing paper in Nature Communications: nature.com/articles/s4146… A collaborative project led by Alex Fedorec including major contributions from Neythen Treloar, Ke Yan Wen, and many others.

Congratulations to Dr Dr Mehmet Yalchin DrYalchinSays for passing his PhD today. A tour de force exploring clonal evolution in #IBD. Thanks James Kinross & Simon Buczacki for examining. The ICR Barts Cancer Institute (Queen Mary) Imperial Medicine St Mark's Hospital Foundation

🎉 We're at #ExRdFest today! We're here 12-6pm today and tomorrow – come say hi and find out about #CancerResearch 👋 Find us in the Sir Alexander Fleming Building Imperial College London, in the Creative Science zone. CRUK Convergence Science Centre #PublicEngagement #SciComm

New #vacancy for a Lab Manager to support the 11 labs across our Division of Molecular Pathology The ICR, which includes our Centre for Evolution and Cancer Centre for Evolution and Cancer, ICR. Details here: jobs.icr.ac.uk/vacancies/961/… JonesLabICR Kamil R Kranc Alejandra Bruna Lab Bezzi Lab Paul Huang Lab

This a great piece: simple everyday things we can do reduce our risk of cancer. Charles Swanton theguardian.com/lifeandstyle/a…

I think this is a really cool study: evolution and heterogeneity predict long-term outcomes in prostate cancer. Worth emphasising that the lab team were blinded to clinical outcomes until a final great reveal: no risk of over-fitting here! Congrats Andrea Sottoriva and team

Over the moon to be appointed Professor of Gastrointestinal Biology at Queen Mary University of London. Many thanks to Nicholas Wright ,Trevor Graham , my collaborators and those in my group past and present whose support was everything Barts Cancer Institute (Queen Mary) Queen Mary University of London Science and Innovation at Cancer Research UK

.QingliGuo has been sleuthing through cancer genomes... she realised that long indels in mismatch repair deficient (MMRd) tumours are totally distinct from sequencing noise, so enable v. sensitive and robust detection of MMRd even for poor quality data & ultra-low tumour content