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Very excited to share that in a few short weeks I will be starting as an Assistant Professor at Western University in Physiology and Pharmacology Phys Pharm! If you are interested in immunometabolism and metabolic disease please reach out! Hiring at multiple positions!

I feel so lucky to work with this group of amazing young scientists! Thanks for the (totally unexpected, you completely surprised me☺️) cakes at the lab meeting today! #HappyPI #LoveMyLab #LoveImmunology

Did you ever wonder why the risk for subsequent vascular events is increased after a first stroke or MI? Our answer, out now in nature nature.com/articles/s4158… A story about NETosis, DNA-sensing and inflammasome activation. Spearheaded by Stefan Roth and Jiayu Cao.

#CoagulationAndImmunity! Ryu, Katerina Akassoglou &co show nature that the #SARSCoV2 Spike binds & activates #fibrin, driving type I interferon signaling, macrophage activation, NK cell inhibition, & neuroinflammation, independently of infection! #LongCOVID nature.com/articles/s4158…

Delighted to share new work from my PhD along with Christian Peace and Luke O'Neill on how itaconate regulates IFNs in Nature Metabolism. Check out the Tweetorial below!

A real pleasure to present our work on the roles of #interferons in #immunothrombosis in beautiful Munich @LMU_Uniklinikum this week! Many thanks to @nicolai_leo and Konstantin Stark for the invitation to speak and mentors Luke O'Neill and Ivan Zanoni for their support.

#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper Cell with Achille Broggi! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OAL7PXqSL5

Leaving Boston in a few days after a productive time in the Zanoni Lab at Boston Children's and Harvard Medical School. Huge thanks to Ivan @lozanzi and the whole lab for their support and inspiration. I will miss you all! Excited to keep working together on cool science! 🤩

The Galvan-Pena lab is hiring a postdoc! If you know of any PhD students who will graduate soon or recently graduated, and are interested in studying gut immunology and the systemic effects of the microbiome, please send them my way.

🚀 TL;DR: pip install kinase-library 🚀 We are excited to introduce #TheKinaseLibrary Python package! 🧵👇 The Kinase Library Jared_Johnson Tomer M. Yaron-Barir Cell Signaling Technology pypi.org/project/kinase…

#JoinUs! Today 4pm, Modell Center, I’ll be giving the Harvard Medical School Harvard University #Immunology seminar, tons of unpublished data, all about how we sense & respond to microbial & host-derived inflammatory signals during infections & sterile inflammatory diseases!

New publication from our group in Nature Communications led by Gemma Leon Preston Lab ICVB RCSI Thanks to our collaborators at Trinity College Dublin CHI at Crumlin and to Research Ireland CHI at Crumlin for funding. Open access link: rdcu.be/d93ds

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses #immunometabolism nature.com/articles/s4158…

#EveryCellIsAnImmuneCell! Jie Yang Roychoudhuri Lab &co show nature that platelet-derived thromboxane A2 suppresses T cell functions favoring melanoma metastases! Aspirin or COX1 inhibition or deletion in platelets reduce metastases! #ScienceMatters doi.org/10.1038/s41586…

Not sure how useful this site is for recruitment these days, but we are looking to recruit a new postdoc asap to a funded position in our lab in Dublin. Please check out our lab website, prestonlab.ie and get in touch if interested.

Trained immunity imprints memory to subsequent infections, but it comes with the caveat of lowering the threshold for blood clots 🩸 by upregulating procoagulant tissue factor. Congrats to Dr Aisling Rehill🇮🇪🇺🇦🇵🇸, Roger Preston, and co on this important discovery. Science Advances

Factor XII drives thrombosis but is dispensable for hemostasis, making it an anticoagulant drug target. We show that factor XII–triggered coagulation traps pathogens and limits bacterial dissemination, highlighting a role of prothrombotic mechanisms in innate immunity.

#EpigeneticPower! Ivashkivlab_HSS Mishra &co show Nature Immunology that anti-inflammatory IL-10 epigenetically silence IRF1 & IRF5 gene transcription by decreasing H3K27ac & chromatin accessibility, thus preventing sustained #interferons & IL6/TNF signaling! nature.com/articles/s4159…

Integrated analysis of transcriptional and metabolic responses to mitochondrial stress #mitochondria sciencedirect.com/science/articl…

#TheMoreTheMerrier! Kami Pekayvaz Nicolai, Stark &co show Immunity that non-classical monocytes help to resolve thrombi by recruiting neutrophils that become thrombolytic following hypoxia-induced programs! cell.com/immunity/fullt…