Light is the source of color! From Yu-Hua Tseng and colleagues, they show a light-responsive metabolic circuit involving adipose-hypothalamus communication. pubmed.ncbi.nlm.nih.gov/39117652/

A new replication test, ScreenDMT, reveals that people with lower BMI have higher levels of linoleic acid diols 12,13-diHOME and 9,10-diHOME, which upregulate adipocyte calcium influx. jonathan dreyfuss Yu-Hua Tseng Joslin Diabetes Center Niven R Narain BERG doi.org/10.1038/s42003…

The endothelin system is traditionally known for regulating vasoconstriction/dilation. Our new paper in Nature Communications shows EDN3-EDNRB induces the browning of human white adipocytes via cAMP-EPAC1-ERK activation. shorturl.at/Os6ET Chih-Hao Wang, Tadataka Tsuji, Farnaz Shamsi

Thrilled to co-lead this new study with Ling Xiao on how m6A modification in brown adipose tissue shapes systemic insulin sensitivity! Our research uncovers prostaglandins as key drivers of improved insulin response.#m6A #insulinresistance share link: authors.elsevier.com/c/1jkhG5WXUlWk…

Online now! Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence dlvr.it/TDdSlb

New paper by Pedro Latorre Muro published in Cell! We combined thermoregulatory physiology, structural and computational approaches to determine the mechanisms of electron transfer and structural basis of respiratory complex adaptation to cold temperatures.

Congrats Kate Korobkina et al for our Nature Metabolism paper online now showing that in brown fat—a thermogenic tissue famous for generating vast amounts of acetyl-CoA in mitochondria—cytosolic acetyl-CoA synthesis also matters…ALOT. Find out why here: rdcu.be/dWUqM

Our new paper in Cell Systems demonstrates how AlphaFold can predict the binding between ligands and cell surface receptors. Congrats Niels Banhos Danneskiold-Samsøe and co-authors from K.C. Garcia lab See paper here: cell.com/cell-systems/a… Stanford Pathology Stanford Diabetes Research

Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in nature. Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite. nature.com/articles/s4158… 1/12 🧵👇

Molecules that activate triglyceride breakdown in brown fat show promise in enhancing energy dissipation as heat. Exciting implications for future #research and #therapies. I2MC-Toulouse Dominique Langin UT3 Paul Sabatier Inserm Etienne Mouisel Carpentier André 5/5 dlvr.it/TGGbFJ

Sarah Crunkhorn from Nature Reviews Drug Discovery wrote this very insightful piece about our latest work in nature on a novel obesity target. NK2R agonist delivers one-two punch to obesity nature.com/articles/d4157… NNF Center for Basic Metabolic Research (CBMR) , European Research Council (ERC) , UCPH Healthscience , University of Copenhagen Research

To my adipose biologists, I'm elated to co-host the inaugural Adipose Biology Conference Adipose Biology Conference with Lawrence Kazak, Hoon-Ki Sung Lab, and Sable Systems International 🐭🐀🧝🏼‍♀️! 📍Montreal, Canada 📅Aug 19-20, 2025 Registration opens Jan 1, 2025. More info in the coming weeks. Tell your friends!

Happy for our new study in Nature Communications at CNIO Stop Cancer leaded by Beatriz Cicuéndez Becas Fundación "la Caixa" and Cintia Folgueira CNIC. A new mechanism that regulates thermogenesis. "MCJ/DnJC15 promotes Brown adipose tissue thermogenesis" nature.com/articles/s4146…

The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice dlvr.it/THL8yc

Fascinating. Why it may be good to be conceived in the cold winter season. More brown fat (which is really good) as an adult. nature.com/articles/s4225… nature.com/articles/s4225…

A powerful and personal editorial from Nobel laureate Ardem Patapoutian: "I owe America my success. Today, its scientific future is in danger." Please read and share. cnn.com/2025/04/09/hea…

Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution go.nature.com/43rCoet

Join us for the 2025 Joslin International Symposium! Save the date and find out more at joslinsymposium.org! Registration is now open, and please consider submitting an abstract.

#MetabolicResearch Metabolite are crucial signaling molecules. I am glad to share MCCP (rc-cbp.tch.harvard.edu/mccp/), a web portal to generate biologically informed, data-driven hypotheses about Metabolite-Mediated Cell-Cell Communication (mCCC). 👇 Use MCCP in computational-free to