Check out this great summary from @aj_inglis of our work characterizing MTCH2 as a transmembrane helix insertase in the mitochondrial outer membrane (in human cells), which is now up on biorxiv. Really satisfying project to work on and a great team to be a part of!

Check out our new preprint identifying MTCH2 as an mitochondrial outer membrane protein insertase in mammalian cells! Great collaboration with Rebecca Voorhees Whitehead Institute Caltech

If you’re not PhDing with BMB Caltech are you even PhDing? Another great BMB student retreat. Thanks to our inspiring keynote Jose Rodriguez José from UCLA.

With lots of new data from the pre-print! I think we finally have a (partial) answer to how alpha-helical proteins get inserted into the mitochondrial outer membrane in human cells. science.org/doi/10.1126/sc…

This work opens a lot of new doors to studying mitochondrial protein biogenesis and quality control. If this sounds interesting to you, we're looking for postdocs to join us in Pasadena, CA Caltech! Check out our website: voorheeslab.caltech.edu

Cellular compartmentation requires stringent sorting of thousands of proteins to their correct destination. Our new pre-print bit.ly/3FjWg7v describes a novel source of specificity that controls sorting of aggregation prone membrane proteins to the correct organelle. 1/8

Purifying eukaryotic proteins & their complexes at the scale & purity needed for structural, functional or mass spec characterization can be a pain! Our new protocol preprint bit.ly/3T5D96c describes how anti-GFP & ALFA tag nanobodies can make your life easier (1/6)

Check out our nanobody-based protein purification protocol. We’ve had great results using this for a variety of applications including cryo-EM sample prep, IDing interaction partner via mass-spec, and functional/biochemical experiments. Very clean and high yield!

Our latest work from Jensen Lab on cryo-ET of Legionella Dot/Icm T4SS is now available on biorxiv. biorxiv.org/content/10.110… Here are some key findings: 1/7

HHMI is proud to announce our inaugural class of Freeman Hrabowski Scholars, outstanding early career faculty in science who have potential to become leaders in their research fields and to create diverse and inclusive lab environments. 1/3 #FHScholars hhmi.news/3ppWfsX

Our lab is looking for postdocs! 🌴🌞 We value scientific and cultural diversity and collaborative science. If you think you could excited about membranes, mitochondria, or microscopes🔬, please get in touch! HHMI Caltech BMB Caltech

We are absolutely thrilled to finally share our new structure from Clemons Lab @Caltech of escape mechanism of the smallest phages (φX174) by breaching the peptidoglycan layer, now out in Science! science.org/doi/10.1126/sc… 🧵 In this thread, I'll give you a sneak peek of the YES complex👇🏼

caltech.edu/about/news/lit… congrats to Anna Karen Orta Nadia Riera (she/her) and the rest of the Clemons Lab @Caltech who made this story possible. This is a long time coming.

Position Open: Postdoctoral Researcher, Tino Pleiner, Stanford University, Stanford, CA jobs.ascb.org/job/postdoctor… Find out more about this position as well as others in cell biology on ASCB's Job Board.

Excited to share my first paper from grad school out today in Molecular Cell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2). cell.com/molecular-cell…

Cool project to work on, congrats to all!

A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in nature for nuclear speckles and mRNA splicing. Check out this thread! nature.com/articles/s4158…

Highly recommend working with Stefan!