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Counterpoint: These is a large scientific literature analyzing how to hire people and select graduate students and we do know which factors predict success more than others. The problem is that most faculty don’t actually seem to ever read it or even care to look it up.

Really neat method for investigating continuous versus heterogenous models of disease. Relevant for lots of traits beyond neuro-psych.

Do individuals with mental health disorders exhibit differences of kind or degree? In a new preprint, we present a novel analytic method called Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) to help answer this question, and then apply it Major

🧬 New Feature in Genomic SEM! 🧬 The new rgmodel() function is now available in Genomic SEM, providing a more precise way to estimate genetic correlations (R) and their sampling covariances (V_R). Let’s break it down! 🧵👇

Interesting article from Kevin Mitchell that develops variational auto encoders (VAEs) as a metaphor for the relationship between genome and organism, with the genome corresponding to the compressed representation. I like the 'generative model' metaphor better than the

Another comparison between the Olink and SomaScan proteomics assays in 3976 plasma samples from Chinese adults. Whatever the two platforms measure is not the same. The median correlation across 1,694 1-to-1 matched proteins was only 0.26❗️

Interesting results with relevance to the missing heritability debate from this preprint. Estimating heritability using whole genome data on 343k European UK Biobank samples, they found heritability estimates of 74% for height and 31% for BMI without much statistical uncertainty

Pitch-perfect response to Interim U.S. Attorney Ed Martin from Georgetown Law Dean Bill Treanor. It’s always a privilege and honor to be part of the GULC community (and to be Bill’s colleague), but *especially* today.

Interesting analysis of cross-sex "genomic structural invariance" (similarity of latent factor parameters) for various psychiatric traits. Some significant but generally small in magnitude differences and no individual sex-differentiated variants. [Schwaba et al. 2025 NG]

Curious about trajectories of biological aging in childhood? Sharing our new article, Stability of Aging-­ and Cognition-­ Related Methylation Profile Scores Across Two Waves in Children and Adolescents: doi.org/10.1111/cdev.1… Laurel Raffington, PhD Peter Tanksley Elliot Tucker-Drob Kathryn Paige Harden

This guy fishes.

We have reached a sale agreement with Regeneron, a leading US-based biotechnology company, to carry forward 23andMe’s mission and maintain customer privacy protections. Read more about today’s announcement here: 23and.me/3ZoX2JT

The ReGPC presents comprehensive GWAS of the Big Five personality in N=611K-1.14M and within-family GWAS in N=51K. In contrast to many other social/behav traits, pop GWAS of personality almost entirely reflect direct genetic effects. doi.org/10.1101/2025.0…

A few days ago, I posted a retraction of an article about the impact of motivation on IQ. Now, I have a blog post documents how the estimated impact of motivation went from 9.4 IQ points to 7.1 points... to 2.5 points. The post also recounts my role in this story of The

1/🧬 New preprint! We introduce the QTrait function, a method to assess the external validity of genetic factor models in Genomic SEM 📄 biorxiv.org/content/10.110… 🧵👇

New preprint! We're all wrong about who's lonely – and about what loneliness is. By failing to just be direct when we ask people if they're lonely, we've been worried about the wrong people🧵🧵🧵