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Thrilled to share that our preprint mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell. Thank you to everyone involved! doi.org/10.1016/j.cell…

It's happening again. We have a big Memorial Day backlog. Any bioRxiv Affiliates around to screen papers, we'd be forever grateful! 🙏

🚀 DeepSeek-R1-0528 is here! 🔹 Improved benchmark performance 🔹 Enhanced front-end capabilities 🔹 Reduced hallucinations 🔹 Supports JSON output & function calling ✅ Try it now: chat.deepseek.com 🔌 No change to API usage — docs here: api-docs.deepseek.com/guides/reasoni… 🔗

People have asked about how MAP-MS works so here's a tweetorial on Teeradon Phlairaharn's new preprint: biorxiv.org/content/10.110…. MAP-MS takes advantage of parallelization in a trapping MS, collecting Orbitrap MS1s with 2x the dynamic range by differentially amplifying parts of the ion beam.

The micropipette—that ubiquitous tool found in laboratories around the world—was invented by a 32-year-old German postdoc in 1957 after a particularly productive two-day tantrum. That first device, made by Heinrich Schnitger, had “all the essential features of the modern

As Eran Mukamel and Yu point out, #methodsmatter. They are spot on here: nature.com/articles/s4158…

We made a huge poster that illustrates all of the major genome editing tools in one place. You can download a copy for free from the Asimov Press website. press.asimov.com/articles/crisp…

New publication in Cell Reports Medicine We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake. sciencedirect.com/science/articl… Morten Hostrup Jeppe Kjærgaard NNF Center for Basic Metabolic Research (CBMR)

Dear #FedEx what the hell is going on with your Newark facility?! FedEx FedEx Help

New in JBC press: "Cryo-EM structures reveal the PP2A-B55α and Eya3 interaction that can be disrupted by a peptide inhibitor." Learn more: jbc.org/article/S0021-…

😮If confirmed, this would be Webb’s first direct image discovery of a planet around another star!

Our exploratory work on sensitivity boosting pre-accumulation, implemented into Orbitrap instruments, has been peer reviewed and published. We learned a lot here, and the method eventually became a commercial product. pubs.acs.org/doi/10.1021/ac…

Scihub stopped uploading new articles. SciDB is a continuing effort which has the entire scihub collection AND new papers. annas-archive.org/scidb

old.reddit.com/r/proteomics/c… User interested to hear from fellow #proteomics and #TeamMassSpec researchers their experience with spatial proteomics on FFPE blocks.

Out NatureStructMolBiol a Review on origin licensing with the most comprehensive (and coolest!) movies on how pre-RC assembly works. Decades of structural and biochemical work are beautifully illustrated. Kudos to Janet Iwasa, John Diffley and Bruce Stillman. nature.com/articles/s4159…

Two great new studies out in nature today, pushing back the recovery of dental enamel proteins to 21+ million years in the Arctic (doi.org/10.1038/s41586…) and 18+ million years in East Africa (doi.org/10.1038/s41586…) #palaeoproteomics!

Astral Zoom hits >7,000 protein groups & 67,000 precursors — on a 500 SPD EvoSep ENO run. biorxiv.org/content/10.110…

🚀 Check out our preprint on the new Thermo Scientific Orbitrap Astral Zoom MS 💫👇🏼 biorxiv.org/content/10.110…

500サンプル/日のスループットで7000タンパク質検出ですと！ただただスゴイ。