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Condensates on transposon(-derived) transcripts and regulation of TDP43-RNA interactions. exciting Transposon-RNA biology by Jernej Ule #EMBOMobileGene

After an extremely long time, members of ule_lab are enjoying an in-person conference in Vienna Vienna BioCenter. What a feeling! 🤗 Miha Modic Martina Hallegger

ule_lab jbc.org/article/S0021-… Latest, a 13C-based assay to quantify the turnover of base modifications in newly transcribed RNA, by mass spectrometry. We uncover the origin of RNA modifications in digested RNA, and assess their sensitivity to metabolic stresses.

TODAY, 12h, for our #CEDOCSeminar we will have Paulo Gameiro from ule_lab The Francis Crick Institute to talk about "Metabolism & RNA modifications in gene regulation". 🧑‍🔬👨‍🏫 Don't miss it! DM us for the Zoom link 📬🙌

Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin-associated RBPs academic.oup.com/nar/advance-ar…

This is the first manuscript fully done by the Ljubljana satellite of the RNA networks lab! Originated by Aram A G A , an incredible software developer who wrote the code, and then taken over by Klara, a PhD student. Real honour working with such talents!

Congrats Sina! Very valuable findings and new methods SPACE and SPACEmap to isolate chromatin components and identify the chromatin-contact regions with high sensitivity.

Check out our latest preprint entitled “An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene”, out now on biorxiv: biorxiv.org/content/10.110… (1/9)

Wahoo!! Read on for some v. cool insights into how YTH proteins function... in yeast the lone YTH protein is loaded at chromatin & travels to cytoplasm where it helps to couple decay of targets to active translation 👯‍♀️

Great to have been involved in this study, led by FrattaLab and @wardm50, now in Nature! Featuring lab members Oscar Wilkins, plus iCLIP data (of course!) from Flora Lee and Martina Hallegger. Hopefully this can pave the way to effective precision medicine nature.com/articles/s4158…

I feel so lucky to join the wonderful community of researchers at UKDRI!

Great opportunity to join our team (FrattaLab) working on an innovative new gene therapy for ALS/FTD. A mix of novel computational (incl. new machine-learning approaches), molecular & cellular biology, all with a real therapeutic aim. Get involved! Link: tinyurl.com/bddjtjvc

Last few days to go.... please RT

So excited to share our work on RNA motifs in CLIP, which is published here rdcu.be/cViPt! Read more from Klara Kuret here: x.com/KlaraKuret/sta….

💡Opportunity for a Lab Technician to join Prof Jernej Ule's lab (ule_lab)! Join Dr Owen G. James (Owen Gwydion James) and a team of researchers working on the roles of ribonucleoprotein complexes (RNP) and their defects in neurodegeneration👉buff.ly/48r4nei

An opinion piece on how phosphorylation of intrinsically disordered domains selectively alters global protein–RNA binding profiles. sciencedirect.com/science/articl…

How can cellular signalling swiftly & selectively remodel the transcriptome to drive biological transition? How this switch is orchestrated has been a mystery... 🧵 nature.com/articles/s4159…

Honoured to have written this review with Jernej Ule’s lab on the splicing code, spanning modeling, mechanisms and its implication for therapeutics designs. Wonderful teamwork.