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We annotated 18 chromatin states in 66 fetal mouse epigenomes with ENCODE data from 10 assays. Bivalent regions enriched for transcription factors are essential for silencing lineage-specific genes. Arjan van der Velde, Ph.D. Kaili Fan Jill Moore Zlab@UMassMed rdcu.be/cfCRn

Excited to share our review on SINE elements, their regulatory functions, and disease implications! annualreviews.org/doi/10.1146/an… Xiao-Ou Zhang Zlab@UMassMed Annual Reviews

New Zlab@UMassMed preprint on annotating TSSs active in 100+ cell and tissue types using ENCODE Project RAMPAGE data.

We performed a comprehensive analysis on ~9000 promoters that have open chromatin in most cell types in human and mouse. They belong to cell-essential genes and show distinct regulatory mechanisms. Kaili Fan Jill Moore Xiao-Ou Zhang Zlab@UMassMed @NAR_open doi.org/10.1093/nar/gk…

Glad to be part of this work on optical mapping of human DNA replication led by Nick Rhind! Our results support the stochastic model of eukaryotic replication. Zlab@UMassMed sciencedirect.com/science/articl…

Our collaborative work with Kevin Struhl has just been accepted by Elife: transcription factors YAP and TAZ are recruited by JUNB and STAT3 during breast cellular transformation. prod--journal.elifesciences.org/articles/67312 eLife - the journal Zlab@UMassMed Mingshi Henry Pratt Justin

The fly THO complex silences transposons by promoting piRNA synthesis. Our new work with Bill Theurkauf in Mol. Cell. shows THO can silence a subset of transposons directly without reducing piRNAs. authors.elsevier.com/c/1dnEZ5Sx5gmJ… GEN ZHANG Zlab@UMassMed Tianxiong (Bear) Yu Developmental Cell

Congratulations Kaili Fan on your successful PhD defense! We're so proud of you and we can't wait to see what you do in the future! UMass Chan Medical School Zhiping Weng

My student Kaili Fan defended her PhD thesis today! Congratulations! Kaili Fan Zlab@UMassMed @UMassBioInfo

My MD/PhD student Henry Pratt defended his PhD thesis on Sep 12, 2022; congratulations! Henry Pratt Zlab@UMassMed Zhiping Weng @UMassBioInfo

Now online! A-MYB/TCFL5 regulatory architecture ensures the production of pachytene piRNAs in placental mammals Tianxiong (Bear) Yu Zlab@UMassMed ZamoreLabUMass Deniz M. Ozata rnajournal.cshlp.org/content/early/…

Michael was very good to a lot of us at UMass Chan, and we enjoy his cutting humor. He was a brilliant scientist and a wonderful colleague.

The ZoonomiaProject’s sequencing of more than 240 mammal genomes is paving new roads for understanding mammalian diversity and evolution and ourselves. Learn more in a new special issue of Science: scim.ag/2oO #Zoonomia

The diversity of life on earth is the result of billions of years of genetic kaleidoscope of "endless forms most beautiful" Endless mutation Endless trial and error Endless forms most wonderful have been, & are being, evolved (thanks, Darwin!) #Zoonomia

As part of the Zoonomia consortium, UMass Chan BIB alum Kaili Fan and student Greg Andrews from the Zlab@UMassMed studied the evolution of human regulatory elements, discovering interesting dynamics within mammals. science.org/doi/10.1126/sc…

Researchers in Science have pinpointed parts of the genome linked to a few exceptional traits in the mammalian world, such as extraordinary brain size, superior sense of smell, and the ability to hibernate during the winter. scim.ag/2r4 #Zoonomia

Evolution of human regulatory elements among 240 placental mammals: our paper in the Zoonomia package published in Science. Zhiping Weng Kaili Fan Henry Pratt Jill Moore Elinor Karlsson (elinork.bsky.social) Kerstin Lindblad-Toh Lab UMass Chan Medical School @UMassBioInfo Science Magazine

News coming out of Morocco is horribly tragic in the aftermath of the earthquake. Any suggestions for organizations on the ground that we can support?

Excited that we will be co-leading the DAC with Zhiping Weng (fearless leader) Jill Moore & William Stafford Noble for the new Multiomics for heath and disease consortium. nih.gov/news-events/ne…

Mathieu Lupien Zhiping Weng Jill Moore William Stafford Noble If you could point me to some papers that highlight the differences between the different types of sample prep that would be great. I am collating as much information as possible to enable sound decisions at the early stages. Any feedback is appreciated.