Brand-new preprint from our lab investigating tight-junction formation in #podocyte filtration slits feat. #superresolution 3D-SIM. Let me briefly walk you through the short story: biorxiv.org/content/10.110…

#GraphicalAbstract doi.org/10.1016/j.kint… David Unnersjö-Jess #FSGS #IgANephropathy

Our podocytes imaged with a new fast and simple protocol on the cover of the latest issue of Kidney International 🔬🥳

Great course coming up! This five-day comprehensive online microscopy course focuses on stimulated emission depletion microscopy (STED) and its application to biological questions. #EMBLSuperResolution Leica Microsystems Apply now: embl.org/about/info/cou…

Insights into Glomerular Filtration and Albuminuria | NEJM nejm.org/doi/full/10.10… Thomas Benzing and David Salant

Chronic kidney diseases generally arise from a disordered kidney filtration barrier within glomeruli. This review describes the roles of glomerular capillary pressure, the glomerular basement membrane, and podocytes in regulating glomerular filtration and permeability.

Happy to share our new mini review in Kidney International with Victor Puelles and John Bertram on new insights into kidney development and disease enabled by tissue clearing. Clearly imaging and quantifying the kidney in 3D sciencedirect.com/science/articl…

New preprint which I co-first authored together with superstar Linus Butt , Kasia Bozek performed some DL magic on podocyte foot processes to completely automate quantification of morphology. Thanks to all collaborators. biorxiv.org/content/10.110…

New preprint for all you paraffin embedding-lovers out there, with Amer Ramdedovic Linus Butt Martin Höhne Bernhard Schermer and others.

We are pleased to announce that HRH Prince Daniel of Sweden visited the SciLifeLab facility&visited the prestigious kidney research project in which beside other systems our #STEDYCON is used. Project is represented by Dr. David Unnessjö-Jess&MD/kidney clinician Sigrid Lundberg.

our new paper out in JASN. Terrific work by David Unnersjö-Jess and Linus Butt together with Bernhard Schermer Markus Rinschen

In the past decade, new optical imaging techniques have been developed for visualizing parts of the filtration barrier. This study investigates how clearing and swelling protocols perform with paraffin embedded tissue/biopsies bit.ly/KID0005882021 David Unnersjö-Jess Amer Ramdedovic

📣 🆕 𝗜𝗦𝗡 𝗩𝗜𝗗𝗘𝗢 𝗔𝗕𝗦𝗧𝗥𝗔𝗖𝗧 𝗦𝗘𝗥𝗜𝗘𝗦: A mathematical estimation of the physical forces driving podocyte detachment. 2021 from Kidney International kidney-international.org/article/S0085-… Linus Butt David Unnersjö-Jess Martin Höhne Bernhard Schermer

Assessment of the ultrastructure of podocytes at the glomerular filtration barrier is essential. This study successfully modifies protocols to allow for deep three-dimensional STED and confocal imaging of FFPE kidney tissue bit.ly/KID0005882021 David Unnersjö-Jess Amer Ramdedovic

Bozek Lab is hiring! Do you want to join our team and work on really cool machine learning problems in medicine? Apply! bozek-lab.cmmc-uni-koeln.de/career-openings

New preprint out. Using 3D high-resolution imaging, we found that the orientation of podocyte processes is likely governed by the mechanical forces acting on them. Thanks to all co-authors! Amer Ramdedovic Linus Butt Martin Höhne Bernhard Schermer biorxiv.org/content/10.110…

Our study on deep learning-based segmentation and multi-parameter morphology analysis of foot processes is online! Thanks for a great collaboration Linus Butt Kasia Bozek Martin Höhne Bernhard Schermer kidney-international.org/article/S0085-…

Deep learning–based segmentation and quantification of #podocyte foot process morphology suggests differential patterns of foot process effacement across #kidney pathologies doi.org/10.1016/j.kint… #ArtificialIntelligence #pathology KTH Royal Institute of Technology Universität zu Köln

New paper out where we show that podocyte processes are not randomly oriented on glomerular capillaries. Thanks to all the great people who contributed! Linus Butt Amer Ramdedovic Martin Höhne @HBrismar Bernhard Schermer

We perform a fully unsupervised analysis of the filtration barrier in kidney and show that it allows to group images in a way that reflects their morphometry: frontiersin.org/articles/10.33… Great collaboration with the NephroLab David Unnersjö-Jess Linus Butt !