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We are looking for a PhD student to join our lab at IOCB Prague to study chromatin associated complexes. #structuralbiology #nmr #cryoem #transcription #epigenetics @iocbionmr uochb.cz/en/open-positi… instagram.com/p/ChsE3UfDw2C/…

My lab Caltech Chemistry & Chemical Engineering is #hiring! Looking for a postdoc to join us in sunny Pasadena and tackle questions related to IDPs, phase separation, and transcriptional control using diverse experimental approaches. Please RT. Details and how to apply: nature.com/naturecareers/… #jobs

Extensive multivalent interactions between #BRCA1/#BARD1 E3 ligase IDRs & #nucleosome substrates facilitate chromatin recruitment & contribute to histone H2A ubiquitylation and to DNA repair @SamWitus et al Klevit Lab UW Biochemistry Zhao Lab UT Health San Antonio embopress.org/doi/10.15252/e…

Although we were not successful in resolving the central IDR from LEDGF bound to nucleosomal DNA using #cryoEM, we stumbled upon an unexpected H3K36 methylation-independent docking site for its PWWP domain. This story was just published in Nucleic Acids Res and is summarized by Eliš Ká

Addicted remodeler caught red-handed. Excellent job Katerina Cermakova, cermakova.bsky.social and H. Courtney Hodges!

For the first time, we find a common mechanism for SWI/SNF addiction in cancer. Our paper reveals that G1 phase is a critical moment for SWI/SNF activity in several addicted cancers, including neuroblastoma, AML, prostate cancer, and uveal melanoma academic.oup.com/nar/advance-ar… (1/6)

What do SWI/SNF-addicted cancers have in common? And when are they most sensitive to SWI/SNF inhibition? Check out Katka’s Tweetorial highlighting our most recent paper

A proud moment in the life of PI. Well done Dr Eliš Ká ⭐️

I am incredibly proud to present our paper on pioneer factor Sox2 that is now out in Nature Communications nature.com/articles/s4146… Work led by Sveinn Bjarnason and Jordan McIvor, with Davide Mercadante, Birthe B. Kragelund Andreas Prestel Kinga Demény, Jakob Bullerjahn.

Now online! APOBEC3A and APOBEC3B drive distinct mutational landscapes in tumors. We showed how A3A and A3B substrate preferences for different hairpin structures can be exploited to identify patients' tumors with mutations caused by either A3A or A3B. nature.com/articles/s4146…

Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers academic.oup.com/nar/article/do…

Exciting news! I am grateful and thrilled to join the Section for Biomolecular Sciences #UCPH. We use single-molecule tools to study how pioneer factors interact with chromatin and promote cell reprogramming. Join our ERC-project PIONEER, now recruiting on all levels!⬇️

Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein–protein interactions doi.org/10.1093/nar/gk…

Nucleosome flipping drives kinetic proofreading and processivity by SWR1 nature.com/articles/s4158…

🚀 Exciting News! Our latest research on the structural basis of MICAL autoinhibition has just been published in Nature Communications ! This study sheds light on the mechanisms that control MICAL proteins, which play a critical role in cellular dynamics and processes like axon guidance.

Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered??? nature.com/articles/s4158…

Check out our new preprint on transcription-coupled H3K36me3 deposition by Set2 and RNAPII elongation complex (EC)! We visualized EC-bound Set2 capturing reassembled upstream nucleosome intermediate after downstream nucleosome disassembly! biorxiv.org/cgi/content/sh…

Exploring unsettled biomolecular interactions with an NMR twist. A joint effort with the Obsil lab. IOCBioNMR nature.com/articles/s4146…

Our new paper has been published! In this study, we revealed the mechanism by which the efficient transcription by RNA polymerase II is accomplished on nucleosomes containing a histone variant H2A.B. #cryoEM embopress.org/doi/full/10.10…