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Our latest study in PNASNews reveals that targeting EPHB2/ABL1 with dasatinib reprograms the immune microenvironment and leads to tumor regression in preclinical ependymoma models. This work paves the way for new therapeutic strategies! doi.org/10.1073/pnas.2…

NEW content online! Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer bit.ly/3X7JGAu

Use of math modeling and AI can improve delivery and efficacy of cancer therapies. New article of our Cancer Biophysics Lab at University of Cyprus in collaboration with Edwin L. Steele Laboratories , Harvard Medical School published in Nature Reviews Cancer nature.com/articles/s4156…

nature.com/articles/s4156…

#REVIEW 🚨 Triantafyllos Stylianopoulos & Rakesh Jain & Co review the utility of continuous models & discrete models in therapy delivery and efficacy in cancer and propose ways to integrate mechanistic and AI-based models to improve patient outcomes. 📖 👇 bit.ly/3X7JGAu

frontiersin.org/journals/cell-…

We’re thrilled to share that our director, Dr. Rakesh K. Jain, has been awarded the 2025 AACR Award for Lifetime Achievement in Cancer Research! His pioneering work in tumor microenvironment & vascular normalization has shaped modern cancer therapy. aacr.org/about-the-aacr… AACR

Bone marrow vessels are hyperpermeable to macromolecules and nanoscale medicine in a size-dependent manner. | Kazunori Kataoka, Kawasaki Institute of Industrial Promotion | [Open Access] #TransvascularTransport #intravital #microscopy kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Normalization strategies can lead to complete cure in murine breast tumor models. New article of our Cancer Biophysics Lab in J Cornelius Sonopermeation combined with stroma normalization enables complete cur... sciencedirect.com/science/articl…

Sonopermeation combined with stroma normalization enables complete cure using nano-immunotherapy in murine breast tumors. | Fotios Mpekris University of Cyprus | [Open Access] #sonopermeation #mechanotherapeutics #MachineLearning kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Rakesh Jain, PhD, director of the Edwin L. Steel Labs, has been honored with the 2025 AACR Award for Lifetime Achievement in Cancer Research for his work in tumor biology research. #AACR25 spklr.io/60157kdT

Honored to see Dr. Rakesh K. Jain, recognized with the AACR Award for Lifetime Achievement in Cancer Research at the #AACR25 Annual Meeting in Chicago! Edwin L. Steele Laboratories #CancerResearch

It was great to see our very own Rakesh Jain, PhD, FAACR, from Edwin L. Steele Laboratories receive the Lifetime Achievement in Cancer Research from AACR at #AACR25! Congrats! Read more: aacr.org/about-the-aacr… Mass General Cancer Center

Honored to celebrate Dr. Rakesh Jain’s inspiring AACR 2025 Lifetime Achievement Award! 🏅 His keynote on “Normalizing the Tumor Microenvironment” was a masterclass in translational science. A proud moment for Edwin L. Steele Laboratories and Mass General Cancer Center! AACR #AACR25 Ludwig Cancer

📢 New preprint from TIME Lab! Research scientist Golnaz Asaadi Tehrani and colleagues have been studying the reprogramming effects of HDAC inhibitors on cancer and immune cells in 3-D models of glioblastoma #epigenetics #immunoepigenetics #GBM #chemo researchsquare.com/article/rs-657…

Dr. Rakesh Jain @SteeleLabsMGH shared insights from his decades-long work on vascular normalization—from concept to clinic. His lecture emphasized strategies to improve tumor vessel function and how these principles are transforming cancer therapy at #AACR25 Harvard Medical School

Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy A new study from Edwin L. Steele Laboratories , Cancer Biophysics Lab and MD Anderson Cancer Center , University of Cyprus, Harvard Medical School with lancemunn, Rakesh K Jain, Jen Wargo! aacrjournals.org/cancerres/arti…

Νέα μελέτη του Πανεπιστημίου Κύπρου αναδεικνύει τον ρόλο του μικροβιώματος στην ανοσοθεραπεία linkedin.com/pulse/%CE%BD%C…

Excited to share our new review on immune checkpoint blockade in the tumor microenvironment, now out in Nature Cancer. Congrats to the whole team. nature.com/articles/s4301…

new article from our Cancer Biophysics Lab in collaboration with Fotos Mpekris and Cyprus Institute of Neurology and Genetics!