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We report that simply clustering a MSA lets #AlphaFold predict multiple states of fold-switching proteins. We used this to screen for alt states in proteins without known fold-switching, and describe one such predicted novel state for the DsbE enzyme. 1/n tinyurl.com/4ewfxf7x

Here is our tweetorial on this crazy story, led by @coraline_mly from my lab. science.org/doi/10.1126/sc…

Exactly 10 years after Nikolaus Rajewsky first work on circRNAs and Cdr1as, we digged a little deeper and described how the interaction between two non-coding RNAs can drive modulations in excitatory synaptic transmission and more...

scDNA methylation predictor of age biorxiv.org/content/biorxi…

Attention all #MachineLearning experts! Join our team Max Delbrück Center and Arcas to make a real impact on #Cancer #therapeutics. We're on a mission and need your skills to make it happen. Apply now for our #ML Scientist/Engineer roles mdc-berlin.de/career/jobs/2-…

Are you interested in innovations in single-cell genomics? Join us on the 15th & 16th of May at the ISCO conference in Berlin! We have a set of amazing speakers and plenty of room for fun networking and contributions from junior scientists (1/4). mdc-berlin.de/news/events/in…

Transdifferentiation fo cancers cells into macrophages for T-cell training aacrjournals.org/cancerdiscover…

An amazing paper showing how TRIM28 contributes to transposon domestification cell.com/action/showPdf…

Great opportunity to join a great lab and working on a great project. A lot of greatness here!

🚨🚨🚨 We are recruiting a postdoc to work on alternative splicing at single cell resolution at MDC-BIMSB in Berlin! Please RT! More details below 👇

🚨 We are recruiting! 🙏Please RT 📢 We offer a FPI fellowship to work on enhancer-promoter 3D communication at Centro Andaluz de Biología del Desarrollo 📨 Send your application to [email protected]

Debbie Caswell Charles Swanton & I had the pleasure of highlighting a fascinating study from Jacks Lab Peter Westcott👏 Tumour heterogeneity undercutting immunogenicity in MMRd Well worth a read esp. the 🔴🟠🔵🟣clonal mixing/neoantigen tetramer assays🎇 nature.com/articles/s4158…

What are the molecular effects of a single drug exposure 💉 on reward system #dopamine neurons 🧠? We found an unexpected role of 3D genome 🧬 structure in long-term cellular memory of a single #cocaine exposure. Dominik Szabó vedran franke Warren Winick-Ng Prof Ana Pombo MDC-BIMSB 1/6

We hypothesized that boosting RNAi could boost antiviral immunity. In vivo. We genetically engineered a mouse with 10x stronger RNAi and infected it with CVB3, TBEV, EMCV, LCMV. It didn't work. Mice are available to anyone who wants to test other viruses. biorxiv.org/content/10.110…

I wonder if GNU Guix could also be an alternative. currently, there are 28000 packages, and many data science packages are there including PyTorch. packages.guix.gnu.org harder to package for GNU Guix as it is built for reproducibility, but they have been building some