🎉 Our latest preprint is now online 👉 biorxiv.org/content/10.110… Congrats to Ralf Steinhilper who determined #cryoEM structures of the ferredoxin 2-bound core iron-sulfur cluster assembly complex under reducing and turnover conditions at 2 Å resolution. More below! 👇 🧵 1/8

Heartfelt congrats to @pornelas9 on defending her #phd thesis with the highest distinction "summa com laude"👏🥳She was celebrated with a #mitochrondrium piñata reflecting her studies of the outer mitochondrial translocase by #cryoEM 🪅🔬 We wish her much success for her future!

Introducing aerotrophy! New preprint shows that aerated caves are continually energised by atmospheric trace gases. The most abundant and active microbes fix carbon using hydrogen and methane gas. Huge collective effort led with @Sean_K_Bay and @chownlab. biorxiv.org/content/10.110…

Molecular cloning: a ubiquitous and essential molecular biology technique. It's also the reason many scientists become superstitious, some equating cloning to witchcraft. But why, and does it have to be this way?

Happy to see our study on the structure of 46-kDa Streptococcus pneumoniae NOX out in NatureStructMolBiol! Congratulations to the authors Pablo San Segundo and Victor Dubach 🥳 Check it out here (open-access) 👉 t.ly/T0oej

This is rich - one of the primary reasons scientists don't have a lot of time to think is that @nature and its ilk have promoted a culture where the primary goal of science is to produce bloated Nature papers that require lots of time and money, but little thought, to produce.

Snapshots of acetyl-CoA synthesis, the final step of CO2 fixation in the Wood-Ljungdahl pathway biorxiv.org/cgi/content/sh… #biorxiv_biophys

Check out this amazing story on carbon fixation and acetyl-CoA synthesis from our group Murphy Lab! Many congrats to Max Yin and all authors 🎉

Two open fully funded Postdoc positions in my lab in #cryoEM & #cryoET. See description below 👇Please share and spread the word. For all those interested in joining my group and work on exciting and collaborative projects please apply! drive.google.com/file/d/1Qs4roS…

Check out our article on the tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel! This work, combining SPA cryo-EM, cryo-ET and MD simulation, was made possible by the collaboration between Misha Kudryashev 🔬 ❄🕊️, Prof. Vogel and Dr. Yuan labs. embopress.org/doi/full/10.10…

Happy to share our recent work on symmetry of loop extrusion by SMC complexes! The work from @BisLightyear @Ekimlab biorxiv.org/content/10.110…

Congratulations @jakobsilberberg on the successful defense of your doctoral thesis Goethe-Universität. You passed with flying colors! Thank you for everything and all the best for your (scientific) future!

My babies are on the cover of The EMBO Journal! I couldn't be happier and prouder of this journey alongside with my colleagues and collaborators, which has led to this amazing publication. Enjoy it once again!😌 Misha Kudryashev 🔬 ❄🕊️ Max Planck Institute of Biophysics

Congratulations again to all the winners (Eszter pictured in action) and many thanks to Biophysics Colab for the sponsorship! Victor Dubach @elodinsky

❄️🌈 Now out in Nature Methods: nature.com/articles/s4159… Couldn’t be happier!

Amazing work by Olivia Pfeil-Gardiner Olivia Pfeil-Gardiner et al. from the Murphy Lab! Using STEM-EELS, they mapped specific elements within protein structures, demonstrating the power of *reconstructed electron energy-loss (REEL)* analysis. 👀👉nature.com/articles/s4159…

Excited to share our AI+cryo-EM work! 🧬 🔬 Cryo-IEF: Foundation model trained on 65M particles 🤖 CryoWizard: automated structure pipeline 🎯 Making cryo-EM accessible to more labs Preprint: biorxiv.org/content/10.110… Code: github.com/westlake-repl/… #CryoEM #AI #StructuralBiology

I‘m happy to share our work on laser flash melting to overcome preferred orientation in cryo-EM samples! 🥳❄️🔬 More infos on the underlying mechanism of particle redistribution and the use for preferred orientation issues in the 🧵 or here: biorxiv.org/content/10.110…

Agalya Periasamy et al.: Structure of an ex vivo Drosophila TOM complex determined by single-particle cryoEM #MitochondrialTranslocases #SingleParticleCryoEM #TOMComplex @unimelb ANU Media... #IUCr journals.iucr.org/paper?S2052252…

Authors Ralf Steinhilper and colleagues from Murphy Lab, Max Planck Institute of Biophysics, Philipps-Universität map ferredoxin-2 binding to the core mitochondiral iron-sulfur cluster assembly complex. nature.com/articles/s4146…