Is alpha-synuclein pathology due to a loss-of-function or toxic gain-of-function? We review some important physiological functions of alpha-synuclein @lauren_komer Weill Cornell Neurology WCM Brain and Mind Research Institute sciencedirect.com/science/articl… (free full text and pdf)

Congress introduced historic legislation for a national plan to end Parkinson’s disease and we fully support it. Read more here: Parkinson.org/blog/awareness… #Parkinsons #Act4PD

We are excited to announce our #Neurology Residency Virtual Open House! Please join our program team and residents at 7PM EST on Wednesday, August 31. Registration: weillcornell.az1.qualtrics.com/jfe/form/SV_eL… Weill Cornell Medicine NewYork-Presbyterian Memorial Sloan Kettering Cancer Center @NMatch2023 #Match2023

📣 Apply to join us in the Burré lab in NYC for exciting bench-to-bedside work on the synapse in neurological disease WCM Brain and Mind Research Institute WCMPostdocs

New work from the Sharma and Burré labs ⁦WCM Brain and Mind Research Institute⁩ ⁦Ying Xie⁩ shows lysosomal exocytosis of alpha-synuclein aggregates from neurons #Parkinsonsdisease nature.com/articles/s4146…

Always been puzzled by the [popular] view that pathologic events have nothing to do with normal protein functions. No system works like that. We will have something to say on this topic soon... the-scientist.com/features/the-m…

Come work with me! The Dept of Biomedical Sciences at the University of Guelph is hiring a neuroscientist! We are an awesome group, with lots of exciting neuroscience research!! Please RT. #QueerInNeuro #BlackInNeuro #WomenInSTEM Details can be found here: uoguelph.ca/facultyjobs/po…

#Cerebellum and #reinforcement learning - what’s your take? Proud to see Dr. Christian Amlang presented our work in #MDS2022! #NeuroTwitter #MovementDisorders

GGGOOOAAALLL we made the cover! huge thanks to the team NatureStructMolBiol Sara Osman for highlighting our work! nature.com/nsmb/volumes/2… 🤩😍🥰😊🥲 feelin' all the feels 🥲😊🥰😍🤩

What the heck is all that extranuclear TDP-43 aggregation doing in LRRK2. Greater frequency in LRRK2 G2019S autopsies compared to PD cases without a LRRK2 mutation. Other papers show TDP-43 in nigra w/o Lewy bodies may be levodopa responsive. …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

✨CONGRATULATIONS to Dr Matthew Perkins Matthew Perkins on his appointment to Instructor! Dr Perkins investigates how the brain constructs neural representations of the internal body w/ specific interest in how distinct motivational states emerge from internal organ function.👏

In opening her lecture, “Early Changes in α-Synuclein Membrane-Binding in the Central and Enteric Nervous System in Parkinson’s Disease,” Emerging Scholar Speaker Virginia Gao, MD, PhD cites James Parkinson, who articulated a connection between the brain and stomach. #ANA2023

Columbia University Weill Cornell Medicine fellow Virginia Gao presenting her emerging scholar research in American Neurological Association #prodromal biomarker session: decreased alpha-#synuclein membrane binding in the gut as early pathological change for #Parkinsons 👏🏼

ICYMI: Virginia Gao, a movement disorders fellow at Weill Cornell Neurology, discussed several topics related to the use of biomarkers in the prodromal stages of neurodegenerative disorders like Parkinson's. neurologylive.com/view/role-gut-…

Congratulations to Virginia Gao, MD, PhD, of Weill Cornell and Columbia on receiving one of the #ANA2023 Emerging Scholars Awards! myana.org/about-awards/e… Weill Cornell Medicine Weill Cornell Neurology Columbia Neurology Residency

Details of House-proposed cuts for 2024 fiscal yr: NIH 6.2% ⬇️ Including: NIGMS 2.6% ⬇️ NCI 2.9% ⬇️ NIAID 22.9% !!⬇️ ascb.org/science-policy… Worried? Call/email your House rep to let them know! The Senate budget included 2.4% ⬆️ for NIH, far preferable.

Perspectives of People At-Risk on Parkinson's Prevention Research Preprints.org preprints.org/manuscript/202… #Parkinsons #LRRK2 #GBA #RBD @JohnPomaRVA Grace Crotty MD MPH Virginia Gao Sergio Castillo Torres Soania Mathur, MD @KB_Schroeder michaeljfox.org Parkinson's Foundation

Coming in at #6 is “Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes” by Virginia Gao, Juan A. Briano, Lauren E. Komer, Jacqueline Burré Virginia Gao @lauren_komer bit.ly/4aC46Hh

Urgent call to the American public and neuroscience advocates to lobby hard against the 40% cut in NIH Brain Initiative Funding. Spread the word and get active! Parkinson and Alzheimer’s as well as neurodegeneration diseases will be dramatically affected. From the Director: ‘The

Congratulations to our Virginia Gao, Carl Crawford (Weill Cornell Medicine GI & Hepatology), Jacqueline Burré (WCM Brain and Mind Research Institute) for an outstanding review on the gut–brain axis in #Parkinson's Disease in Cold Spring Harbor Laboratory Perspectives in Medicine perspectivesinmedicine.cshlp.org/content/early/…