🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

An exciting news if you are interested in nanopore protein sequencing: we could successfully engineer a force capable of transporting polymers across nanopores, even against their charge! go.nature.com/3PpPTDi

Does the amount of plastic garbage, solvent waste, or energy usage in your lab make you cringe? Caroline Seydel reports on what some labs, departments, companies, and funders are doing to lower the environmental impact of life science research. nature.com/articles/s4159…

In what may be one of Earth’s craziest forms of mimicry, researchers have discovered a new species of rove beetle that grows a termite puppet on its back to fool real termites into feeding it. scim.ag/4cM News from Science

Thrilled to share the final publication of CellTag-multi, a strategy in which CellTag lineage barcodes can be captured in both scRNA-seq and scATAC-seq assays allowing for independent tracking of clonal transcriptional and epigenomic state, with Kunal Jindal x.com/NatureBiotech/…

So cute 😮

Benchmarking of scATAC-seq protocols demonstrates the effects of data quality on downstream analyses go.nature.com/3KqmUxG

How does the structure of target DNA affect CRISPR/Cas9 off-target activity during gene editing? We show that negative DNA supercoiling dramatically reduces Cas9 specificity. Find out more here: doi.org/10.1016/j.molc… Molecular Cell LUMICKS MRC Laboratory of Medical Sciences (LMS) The Francis Crick Institute UCL

The Penn Bioengineering PhD program offers support during the application process. If you are interested in Penn BE, or even just graduate school in general, please take advantage. We are here to help! Link: docs.google.com/forms/d/e/1FAI…

Just updated: Download our massive database of postdoctoral fellowships (316!) For each fellowship, we provide a description, link, $ amount, eligibility criteria, and deadline. download this database here: research.jhu.edu/rdt/funding-op…

Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA go.nature.com/4b25IKC

In 2017, I moved to San Diego to start an MD-PhD, an 8-year program. "8-years!" people would gasp, "Is that program even legal?" To show the passage of time, I got a house plant, thinking I’d take a photo at the start and finish, hoping the succulents would thrive as living

A cool paper showing how one can learn the cis-regulatory code using deep learning models. It is great to see the authors go the distance and test the model predictions in vivo.

Check out Vivekanandan Ramalingam talk today at CSHL Meetings #BoG24 in the afternoon session on "Deciphering the cis-regulatory code of TF binding across the ENCODE compendium" 1/

Can anyone look at these two headed planarian and not want to know what happened here? Check out the cool paper from Viraj Doddihal | ವಿರಾಜ ದೊಡ್ಡಿಹಾಳ | pnas.org/doi/10.1073/pn…. In case anyone is wondering his boss A. Sánchez Alvarado cannot regenerate for the most part.

Check out ProCapNet by Kelly Cochran, a robust, local sequence context deep learning model of base-resolution transcription initiation profiles (PRO-cap) that provides deep insights into the cis-regulatory code of initiation & more ... biorxiv.org/content/10.110… 1/

Our preprint updating the compendium of nuclear TFs that likely moonlight in the mitochondria: biorxiv.org/content/10.110… 1/

bZIP factors are the outlier in terms of both the number of TFs found to associate with chrM and the robustness of evidence -- of 72 TFs we have data for 39 and 19/39 show occupancy over chrM. Furthermore, this is often over the same sites in the mitogenome... 11/

23 pairs! The magic chromosome count that helps humans thrive. But what if all our DNA were arranged in just two chromosomes? In this study, we explore this question using budding yeast. 🧵 (1/6) cell.com/current-biolog…

Exciting news! Our work on Hippo pathway TF cis-regulation is now published in Cell Genomics! Check it out here: cell.com/cell-genomics/… Grateful to all co-authors who made this possible! ZeitlingerLab #HippoPathway #cisregulation #TFcooperativity #Deeplearning

We are thrilled to announce the release of Khyati Dalal's (Khyati Dalal) work, leveraging deep learning and experimental techniques to decipher regulatory mechanisms of Hippo signaling in mTSCs. Congratuations! cell.com/cell-genomics/…