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The genetic ancestry labels that the NIH “All of Us” biobank genetic data returns seem likely to add to general confusion about genetics and race/ethnicity [see appendix A here: researchallofus.org/wp-content/the…] 1/n

Yale University researchers are inviting volunteers to participate in a paid brain imaging study on decision-making and eating behavior. Please email [email protected] or visit our website for more information! medicine.yale.edu/ycci/trial/gut… Yale School of Medicine #eatingdisorders

There is an opening for a postdoc in my lab at UT Austin to work in the areas of statistical genetics and mental health and/or cognitive aging. Funding is in place. Our recent work can be found at lifespanlab.com. Please feel to email me directly. [email protected]

Distinguishing different psychiatric disorders using DDx-PRS medrxiv.org/content/10.110…

Presenting µBrain: a 3D atlas of Allen Institute histological slices of the developing brain, and tools for aligning gene expression/brain imaging! A beautiful labor of love led by Gareth Ball DevelopingConnectome Stuart Oldham Aaron Alexander-Bloch Emma R - @metricsemma.bsky.social & others! biorxiv.org/content/10.110…

4 years ago, we ran 16,554 GWASes for 7,271 traits across 6 ancestry groups and released the data to the public along with meta-analysis. After many careful dives through the results, we are happy to present these analyses on behalf of the Pan-UKB Project: medrxiv.org/content/10.110…

New paper "Alcohol consumption and the risk of all-cause and cause-specific mortality—a linear and nonlinear Mendelian randomization study" at IJE: academic.oup.com/ije/article/53… led by Nigussie Kassaw and Elina Hyppönen. Brief thread:

New out in Nature!! With age, women can lose one X chromosome in their leukocytes. What’s the cause/consequence? How does it differ from the loss of the Y chromosome in men? nature.com/articles/s4158… Broad Institute FinnGen FIMM HelsinkiUni National Cancer Institute Cambridge University

‼️ Paper alert ‼️ "Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain" now published in PNAS!! How is brain function organized? Regions vs. gradients? Geodesic vs geometric? We add to the debate! pnas.org/doi/10.1073/pn… 1/

Our paper is now available in Nature Mental Health! 🤩

Introducing real-time PRS-CS! Excited to share our new preprint with Tian Ge. Optimized for healthcare settings, rtPRS-CS ensures patients receive the most up-to-date genetic risk prediction by dynamically updating PRS weights using streaming data. 1/7 medrxiv.org/content/10.110…

"Here, we present two real-world examples demonstrating that sample overlap and relatedness is not a minor or theoretical concern but an important potential source of bias in PRS studies." Ellis et al. AJHG cell.com/ajhg/abstract/…

Excited to share my 1st-author work from the @arbelharpak Lab! We examine the accuracy of polygenic score (PGS) predictions across individuals in the UK Biobank. We make 3 observations that expose gaps in our understanding of PGS “portability”. biorxiv.org/content/10.110… (1/28)

🧠NEW WORK OUT NOW ON THE ARCHITECTURE OF HUMAN CORTICAL FOLDING ! 🧠 in ⁦Neuron⁩ by the one and only ⁦Will Snyder⁩ 🤩 wt dream team ⁦Petra Vertes⁩ ⁦@edbullmore⁩ & fab collabs. 👀🔗& Will’s 🧵⬇️ x.com/will_snyder98/… cell.com/neuron/fulltex…

Excited to share that our new paper in Nature Genetics! Huge thanks to Hailiang Huang and Tian Ge for supervising this project and to Broad Institute, CGM at MGH and PGC Consortium for supporting the research. rdcu.be/dR0sF

Yesterday I wrote a thread about why an infographic circulating was misinformation. I wanted to respond to some comments and questions, offer a new (perhaps more intuitive) calculation (thread)

It took me SEVEN years to figure out that you can save a ggplot as a vectorized .svg file ggsave("file.svg"). The svg file can be opened on powerpoint and it will be completely vectorized, even text are still recognized as text boxes! No more recreating plots on illustrator!!!!!

Our paper (Armin Raznahan AdamT, @dmoracze , Siyuan Liu, Travis Mallard) on sex differences in the genetic architecture of the human brain anatomy is now out in Nature Communications Springer Nature ! rdcu.be/dTUX1 Please see original post below for details…

Having referred to it a few times this week, here is a (IMO) slightly more user friendly derivation of the LD-score regression estimator of heritability and its assumptions: gusevlab.org/projects/hsq/l…

Excited to report our study in NEJM on the discovery of deletions in a long noncoding RNA gene 🧬 (𝘊𝘏𝘈𝘚𝘌𝘙𝘙) as the cause of a newly defined human neurodevelopmental disorder 🧠. 🧵1/10 nejm.org/doi/full/10.10…