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#Phenomics is offering an exciting opportunity for distinguished young scholars to join as #YouthEditorialBoard members, recruited through self-recommendation and selection by the Editorial Board. #Springer Springer Nature Check out our official website or scan the QR code for

Come join our #Editorial team! Phenomics is providing an exciting #opportunity for distinguished young scholars to further disseminate their research as #YouthEditorialBoard #Members. Springer Nature Learn more: springer.com/journal/43657/…

👇news Verve Therapeutics and Eli Lilly and Company establish global collaboration to advance an in vivo gene editing program targeting Lipoprotein(a) for the treatment of atherosclerotic cardiovascular disease ir.vervetx.com/news-releases/…

wonderful work！

Two exciting method papers in Nature Genetics by Olivier Delaneau and team reporting * A new tool (GLIMPSE2) to impute genetic variants accurately from low-coverage sequencing data * A new tool (SHAPEIT5) to phase rare variants to identify compound heterozygotes My favourite is

It's been my great pleasure to collaborate with so many wonderful friends. It has always been a joyful journey : ) Thanks so much! 🎉🎉 🎉

Terrific summary of our recent paper describing an enhanced polygenic score for coronary artery disease: rdcu.be/dgAR3 Paper (open-access): nature.com/articles/s4159…

Polygenic Background Modifies Risk of Coronary Artery Disease Among Individuals With Heterozygous Familial Hypercholesterolemia @RensReeskamp Injeong Shim Amit V. Khera sciencedirect.com/science/articl…

🔥 Hiring a funded postdoctoral fellow position in human genetics! Come join us CGM at MGH Broad Institute Harvard Medical School! 🔥 Apply: partners.taleo.net/careersection/…

Please share your cohorts discovery with us, I am honored to organize a special issue with Aniruddh Patel and Yajie Zhao, 赵亚杰 on large cohort study. GPB, a top 10 journal ranked in Bioinformatics and Computational biology.

10-year ASCVD risk prediction leads to older individuals being prioritized for statins missing opportunities for earlier risk recognition & prevention. Our work led by Sarah Urbut uses genetics & dynamic risk factor trajectories toward intersecting risk *early.*

Nice comparison of MR methods by Xianghong Hu published at AJHG AJHG (sciencedirect.com/science/articl…) - which concludes that the best MR method out of 16 considered is... the method that their group developed!

New in JACC Journals #JACCimaging Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque jacc.org/doi/10.1016/j.… /thread

NEW from Min Seo Kim, MD, MSDH and Xiong Yang An Integrated Germline and Somatic Genomic Model Improves Risk Prediction for Coronary Artery Disease medrxiv.org/content/10.110… Awesome collaboration with Wallace Wang Pradeep Natarajan and enabled by UKBB and TOPMed Broad Institute

NEW preprint led by Min Seo Kim, MD, MSDH Alisa Chen and Yang Sui Metabolic Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related Morbidities O-MetPRS and D-MetPRS 🔹 Leverage 22 metabolic traits from over 10 million people 🔹Derived in UKB, validated

NEW in Circulation: Genomic and Precision Medicine led by Sarah Urbut Genomic and clinical risk factors of CAD display time-varying importance over the life course. The importance of CAD PRS is highest earlier in life and diminishes with older age. Collab with Pradeep Natarajan Mass General Heart MGH Cardiovascular Research Center

Two new papers in Nature Genetics from Patrick Ellinor and team Expanding genetic discovery of rare, structural and common variation in atrial fibrillation Sequencing >50K cases nature.com/articles/s4158… GWAS >180K cases nature.com/articles/s4158…

🚨 Excited to share our new manuscript in @circAHA led by Tiffany Bellomo and team. We evaluated lipoprotein(a) as a prognostic marker for extracoronary atherosclerotic vascular disease progression in UK Biobank. 👉 doi.org/10.1161/CIRCUL… 🧵1/6

Motivated by the favorable lipid indices and CV risk of ANGPLT3 & ANGPTL8 LoF carriers, Eli Lilly and Company developed a combo ANGPTL3/8 mAb (LY3475766). Phase 1 RCT shows that LY3475766 recapitulates lipid patterns from human genetics nature.com/articles/s4159… Nature Medicine

Longdust, a new tool to identify highly repetitive STRs, VNTRs, satellite DNA and other low-complexity regions (LCRs). Similar to SDUST but for long regions. github.com/lh3/longdust