Results of large RCT in over 1000 women to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, just published academic.oup.com/humrep/article…

Review of 303 UK #NIHR publicly funded #RCTs finds that majority (8 out of 10) use Patient Reported Outcomes (#PROs) as primary and/or secondary outcomes. With just under 4 out of 10 trials using a PRO as the primary outcome for the trial. bmjopen.bmj.com/content/11/9/e…

RCT of Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in 607 adults with cystic fibrosis published thorax.bmj.com/content/early/…

Final report of An intervention to support adherence to inhaled medication in adults with cystic fibrosis: the ACtiF research programme including RCT journalslibrary.nihr.ac.uk/pgfar/pgfar091… published

Review of 86 publicly funded cluster RCTs published. Four out of ten trials are still not reporting the observed ICC for the primary outcome and hence not adhering to the CONSORT guidelines. trialsjournal.biomedcentral.com/articles/10.11…

Results of RCT of Endometrial scratch to increase live birth rates in 1048 women undergoing first-time in vitro fertilisation just published. And recommends that ES is not undertaken in this population journalslibrary.nihr.ac.uk/hta/jnzt9406/#…

Review of recruitment to 388 RCTs funded by the NIHR in the past 23 years just published in BMJ Open . It finds six out of ten trials recruit to their final sample size target. But three out of ten trials revised their original sample size target bmjopen.bmj.com/content/12/2/e…

Results of the Journeying through Dementia RCT in 480 people with dementia just published. Finds the JtD intervention is not effective. thelancet.com/journals/lanhl…

Results of a large programme of research on Improving outcomes for women aged 70 years or above with early breast cancer including a cluster RCT just published journalslibrary.nihr.ac.uk/pgfar/xzoe2552….

Had paper publihed with Julia Edwards & Stephen Walters on conditional power assumptions in clinical trials with continuous or binary endpoints when undertaking interim analyses ScHARR Medical Statistics Group @ScHARRSheffield #statstwitter #epitwitter #clinicaltrials rdcu.be/c8AbI

RCT of new breast immobilisation device finds the SuPPORT S4A bra is feasible to use in breast cancer radiotherapy sciencedirect.com/science/articl…

Bracing Adolescent Idiopathic Scoliosis (BASIS) study – night-time versus full-time bracing in adolescent idiopathic scoliosis: study protocol for a multicentre, randomized controlled trial | Bone & Joint boneandjoint.org.uk/Article/10.130…

Congratulation to Louisa Robinson and Phillips Obasohan being presented their PhDs at the #University of Sheffield #graduation ceremony today

New research and cohort study finds large geographical variation in lower limb amputation rates and survival in patients with peripheral arterial disease in England academic.oup.com/bjsopen/articl…

Protocol paper about an RCT investigating the effectiveness of autologous haematopoietic stem cell transplantation versus alemtuzumab, ocrelizumab, ofatumumab or cladribine in relapsing remitting multiple sclerosis (StarMS) just published bmjopen.bmj.com/content/14/2/e…

Large cohort study of nearly 50,000 patients in England with carotid artery disease finds large differences in surgery rates between affluent and deprived areas academic.oup.com/bjsopen/articl…

Supporting physical activity through co-production in people with severe mental ill health (SPACES): protocol for a randomised controlled feasibility trial just published link.springer.com/article/10.118…

Flexor Injury Rehabilitation Splint Trial (FIRST): protocol for a pragmatic randomised controlled trial comparing three splints for finger flexor tendon repairs just published. The trial has already randomised over 400 participants. link.springer.com/article/10.118…

Comparison of statistical methods for the analysis of patient-reported outcomes in randomised controlled trials: A simulation study - Yirui Qian, Stephen J Walters, Richard M Jacques, Laura Flight, 2024 journals.sagepub.com/doi/10.1177/09…

Impact of a national guideline for the management of peripheral arterial disease on revascularization rates in England: interrupted time series analysis | BJS Open | Oxford Academic academic.oup.com/bjsopen/articl…