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Thank you, Georg. I actually retied from the VA and am Professor and MEdical Driector for Preventive MEdicine at the University of Tennnessee Health Science Center. #HYPHIP

#HYPHIP A1: #SPRINT came about because one of the post pressing questions in management of hypertension (consensus of experts) was what systolic BP (SBP) goal we should treat to. NHLBI/NIH decided to support and fund such a trial.

ACCORDI long-term follow-up) did show CVD reduced with intensive BP in Standard Glycemia group. #askasn

I don't think we assessed exercise in SPRINT, but randomization would balance amount of exercise. #askasn

Target BP was <120 in intensive group. Achieved in >50% and most were <130 mm Hg. #askasn

All major BP drug classes distributed similarly across both groups, but more often used in intensive group. #askasn

Chlorthalidone and amlodipine were primary frugs used in diuretic and CCB classes. #askasn

ACEIs and ARBs also used frequently. #askasn

Spironolactone used about 8% of time in intensive group - I would have used even more often. #askasn

SPRINT didn't address targets in eGFR <20. George, any thoughts? #askasn

Chlorthalidone seemed to lower BP fine in stage 3 CKD and in ALLHAT reduced events similarly. #askasn

In SPRINT (& most HTN trials) participants seen/titrated at monthly intervals. Lab 1 month after adding diuretic or RASI #askasn

More visits in intensive group, but not a lot more. Started with 2 drugs or more and got to goal quickly in SPRINT. #askasn

Much more to come soon on renal and CVD outcomes in SPRINT/CKD subgroup. If missed >75 year olds published in JAMA in MAy. #askasn

I agree with George - at least get <130, but <120 was goal in SPRINT. #askasn

JNC 8 couldn't wait any longer and had not idea SPRINT would end early. #askasn

2.8 drugs, but good drugs, often at high doses. Clearly we all see some more severe patients than were in SPRINT. #askasn

SPRINT MIND should be reported early next year. Had to finish 4-year visits. #askasn

Chlorthalidone dose was 12.5-25 mg QAM #askasn

Thank you very much ... #askasn