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Happy to share the lab’s latest research tagging psychedelic-activated neurons in mice. See the post below from first author Jessie Muir for a tweeprint on the work. Thanks to wonderful collaborators Olson Lab Lin Tian, PhD and to our reviewers/editor! science.org/doi/10.1126/sc…

New work from Arc Institute on the cover of Science this week!

One key component of Perturb-Multi is in vivo Perturb-seq of formaldehyde-fixed tissue, enabled by the Flex reagents from 10x Genomics.

Check out the preprint describing Perturb-Multi from Arc Ignite Awardee William Allen, Reuben Saunders (now at Arc), Jonathan Weissman's Lab and Xiaowei Zhuang. A general and scalable approach applied here to mouse liver, Pertub-Multi generates rich, multimodal data that can generate fundamentally

Check out our preprint on Perturb-multi (doi.org/10.1101/2024.1…), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing.

Excited that the Zhuang Lab is now on X!

Thrilled to share Perturb-DBiT — spatial unbiased in vivo perturb-seq with genome-scale CRISPR libraries! Hope you enjoy reading it over the Thanksgiving week 🥰 Kudos to Alev Baysoy, Xiaolong, Feifei, and Paul. & collaboration with Sidi Chen, Hongbo Chi. biorxiv.org/content/10.110…

delighted to share this exciting news with Prof. Xiaowei Zhuang @zhuanglab and Prof. Jonathan Weissman Jonathan Weissman's Lab, on their latest preprint reporting Perturb-Multi: a multimodal in vivo pooled CRISPR screen 🤩 congrats Reuben and William William Allen 👏🍾 biorxiv.org/content/10.110…

My paper is out!! 🎉 "Opponent control of reinforcement by striatal dopamine and serotonin", nature Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain 🧠 THREAD ⬇️ 1/n

Delighted to share this preprint from Prof. Rong Fan Lab Rong Fan and Prof. Sidi Chen lab Sidi Chen on Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT. Congatulations, Alev, Xiaolong, Feifei, Paul, Sidi and Rong!