Well done Rebekah Jones! Your review on PorB in Gc immune evasion is out!! cell.com/trends/microbi… Delighted to collaborate with Ann Jerse Uniformed Services University, Gc expert. You cant ignore PorB in vaccine design!!

Plasmid-phage interactions!

New pre-print from our lab (Iana and Erin) - cool sponge protein that inhibits two defense systems!

Our study demonstrating the broad-spectrum potency of the anti-CBASS sponge protein Acb2 is now updated and in press! tinyurl.com/ycx8xk9k Original thread here: tinyurl.com/2wfz8wc9 & new insights below ⬇️

📚🌐Thrilled to share our newly published paper in Nature Microbiology in which we unravel how plasmids can tip the scales in microbial war and peace.🪖🦠 Big thanks to Gur's lab The Elia Lab Jens Walter Explore the threads below for key findings (1/6): nature.com/articles/s4156…

Applying CRISPRi technology to Acinetobacter baumannii uncovers essential genes in this antibiotic-resistant bacteria, revealing new drug targets and promising avenues for improved treatment strategies. Warren Rose #mBio journals.asm.org/doi/10.1128/mb…

What a start for the PGB lab in 2024 with yet another integron story! This time we uncover how toxin-antitoxin cassettes have shaped the evolution of chromosomal integrons, turning them into giant genetic libraries for fast "à la carte" adaptation! tiny.cc/xwh0wz

New preprint! Ben Adler and I @doudna_lab, in collaboration with Emily Armbruster and @JoePogliano, unveil a mechanism for Hachiman immunity. The punchline - Hachiman is a genome integrity sensor. College of Chemistry @igisci HHMI biorxiv.org/content/10.110… 🧵 1/14

Thrilled to share that our latest study has been published today! We take a look at how the capsule serotypes of Klebsiella pneumoniae influences phage adsorption and infection, and plasmid conjugation efficiency. Thread👇 #Capsule #Klebsiella #Phage #Plasmid #Conjugation

The phiKZ jumbo phages build a protein based nucleus to protect their DNA(!), but what do they do before the nucleus is built? Led by outstanding post-doc Deepto Mozumdar, here we identify host and phage proteins in an immediate early phage lipid vesicle. biorxiv.org/content/10.110…

New preprint from the lab, led by outstanding student Claire Kokontis! (Claire Kokontis) In this work Claire et al. discover Imp1-Imp6, phage proteins required for the selective import of proteins into the jumbo phage nucleus! Imp1 (below) is the special one. biorxiv.org/content/10.110…

OUT NOW 👉 Bacteriophages avoid autoimmunity from cognate immune systems as an intrinsic part of their life cycles Jakob T Rostøl Nuria Quiles Pablo Iturbe Lasa_Lab José R Penadés nature.com/articles/s4156…

biorxiv.org/content/10.110… Thrilled to share our latest latest work on bacteriophage antidefense systems! Through the construction of a phage gene knockout library, we've identified many antidefense genes within a single 60 kb phage. Great effort by Shinjiro.

Excited to introduce AntiDefenseFinder - a free, open source tool that detects anti-defense systems in any genomic sequence. Available here to toggle on/off: defensefinder.mdmlab.fr. Read below for our insights into the >47K detectable systems📈 tiny.cc/8xrizz

Anti-CRISPR enzyme is widespread, specific and potent: as good or better for lytic rep and lysogen stability than a strong non-enzyme! Long running effort in @fraser_lab/BD lab with many contributors (co-led by Daphne Chen and Leah Roe). biorxiv.org/content/10.110…

Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬. Excited to welcome these amazing speakers at Institut Pasteur, since 1887 . Registration will open beginning of November. Abstract deadline February 28. Stay tuned.

Did you know that bacteria remember their past for many generations? In this new preprint from us (Alexis Villani and Senen Mendoza) and Banin lab (Esther Shmidov ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.110…

Cyclic nucleotide signals are a common anti-phage mechanism. How can (jumbo) phage keep up? Sponges! See thread from Iana Fedorova, a very talented post-doc in lab. We (w/ Feng lab) report amazing diversity in ligands bound by phage proteins Tad1/Tad2. 1/n rdcu.be/dYAVS

The lab is now up and running at New England Biolabs New England Biolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃 neb.wd5.myworkdayjobs.com/en-US/NEB_Care…

So happy that I can finally share the results of my first postdoc paper with Michael Baym!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! Here’s a photo of plasmids competing inside cells in a colony (1/n)