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Visited scientists in Israel that were in my lab: Yaron Ilan, Arnon Karni &Keren Regev, Danny Frenkel, Lior Mayo. Was at pro-democracy rally with Lior. Basic work on nasal Protollin for AD and nasal anti-CD3 for MS that Danny and Lior studied in my lab are now in clinical trials!

Received FDA approval to treat Alzheimer’s with nasal anti-CD3 (foralumab) in a 6 month phase 2 trial. Will assess safety, cognition and reduction in microglia PET imaging. Interviewed on Bloomberg News. Here’s link t.ly/cCtDe . Now treating AD and MS. Very exciting!

Just released the music video of my country and western song SPIT ON MY FLOWERS. I wrote it in medical school and this year recorded and performed it with the country band Ward Hayden and the Outliers. Here it is: tinyurl.com/bdz3xyhr. Hope you like it!

Ann & Mitt Romney gave $2.5M to the Brigham to establish the Howard L. Weiner Distinguished Chair in Neurology. Oleg Butovsky is the first incumbent. There was a great ceremony. Here are links to highlights: shorturl.at/hrS02 and my full remarks: shorturl.at/AEGI7

Hollywood Trip. Neurology Grand Rounds at Cedars Sinai on “Immune Mechanisms in Neurologic Diseases.” At movie studio for my next film, LOVE KILLS, a medical thriller. Script done. I will direct. Looking for lead actor. At Cedars I was asked Nobel Prize or an Oscar? I said BOTH.

Spoke at Columbia in NY at "T cells in the Brain" Symposium at ALS Center. My talk: “Nasal Anti-CD3 mAb induces Tregs that Dampen Microglial Activation and Treats Neurologic Diseases including MS, AD and ALS”. Now in phase 2 MS trials and begin AD trials in April. Very Exciting.

I wrote a love song ISLAND OF TIME 20 years ago. “Life’s confusing, crazy at its best; how I love you and need a place to rest” - a universal yearning. Here’s the link to my music video rb.gy/jpjkpf. Hope you like it and can escape with your love to an island of time.

Spoke at Lisbon ADPD “Nasal Immunotherapy of monocyte-microglial axis to treat AD” Here’s link t.ly/nHREi. Nasal Protollin modulates AD monocytes. Nasal Foralumab (anti-CD3) modulates microglia, treats AD/PD models and ARIA. Foralumab AD trial planned. Very exciting!

Received the GIANTS OF MS AWARD in Research, a lifetime achievement award. Hard to believe the years have passed, but still going strong with exciting work on nasal anti-CD3 for progressive MS, MS immunology and the microbiome. Here’s a link to my remarks: tinyurl.com/j4ymcpvu

2nd Annual Weiner Symposium on Immune Mechanisms in Brain Disease held at Mitzpe Ramon Israel in May. Beautiful venue. Wonderful to talk science with top scientists and friends. Outstanding program and great progress being made. More to come in the future.

Treated first Alzheimer’s patient with nasal anti-CD3 (Foralumab) to dampen microglial activation. Very exciting! Has moderate AD - doesn’t qualify for anti-amyloid Rx. Next month we treat mild AD. Touching piece on TV. Here’s a link:tinyurl.com/35ns7djy Hope we can help him!

Published in Nat Rev Neurol on common immune mechanisms in neurologic diseases. Link: tinyurl.com/4jxkpwkn Makes possible common therapy for multiple diseases (MS, AD, ALS & PD) as we are doing with nasal anti-CD3. Was sole author & took year to write. Immunology is so cool.

Just published exciting paper in Nat Neurosci on nasal anti-CD3 in TBI. Link: tinyurl.com/22u6x3vt. Hats off to Saef Izzy! Submitted 10/22 - Rejected; 1/23 - Appeal; 2/23 - Revision; 8/24 - More revisions; 10/24 - Accepted 12/24. Never quit in science! Tregs are so important.

MS Meeting in Palm Beach with Jack Antel from Montreal. We go back 50 years as fellows at Mass General. He was honored and gave keynote lecture. He spoke of my MS cyclophosphamide studies in 1980 that were harshly criticized by Canadians (Ebers and Noseworthy) but ended up right.

In Vienna for AD/PD meeting. My family fled Vienna in 1939 just before Hitler. My grandfather had a big department store in the center of Vienna. He always wanted his grandson to be a doctor. Almost 100 years later I stood in front of his store to honor him and everyone we lost.

ADPD talk in Vienna “Induction of Aβ clearing monocytes by nasal Protollin and of Tregs to dampen microglial activation by nasal foralumab in AD and PD pts”. Showed monocyte transcriptome and decrease in microglial activation by TSPO-PET in 1st AD pt Rx with nasal foralumab.

In unique MS cohort, found gut microbiota and metabolites link to MS progression tinyurl.com/4d86tnym. SCFA-producing microbes, beneficial. Alistipes, detrimental. Fecal metabolites link to progression. Gut is important in MS progression. First published on microbiome in 2016.

Led by Vijay Kuchroo and Oleg Butovsky, our group just published a paper in Nature showing treatment of Alzheimer’s disease by TIM-3 mediated regulation of microglia: tinyurl.com/5572mfb9. Immunology plays a major role in AD over and above anti-amyloid therapy. Very exciting!

Alzforum highlighted my ADPD talk in “Therapies to Tame T cells in the Brain.” shorturl.at/Iek1m. Showed Tarun Singhal’s reduction in microglial PET after nasal foralumab in AD pt & referred to Saef Izzy, Leah Beauchamp & Vik Khurana from MGB all working on nasal anti-CD3.

Posted study of nasal foralumab in progressive MS (PIRA) on MedRxiv: shorturl.at/0PzJt. Decade of work from animals to people. Results beyond expectations & no toxicity! Multi-center placebo trial underway. PIRA is major challenge for MS and we may have a treatment.