Great opportunity to join our team (FrattaLab) working on an innovative new gene therapy for ALS/FTD. A mix of novel computational (incl. new machine-learning approaches), molecular & cellular biology, all with a real therapeutic aim. Get involved! Link: tinyurl.com/bddjtjvc

Plant

24 Thanks for all the snacks💕✨

If you want to know more about my PhD project on tau release in neurons in the The MNP Lab at UK Dementia Research Institute UCL Queen Square Institute of Neurology, come and find me today at my poster 403 in the Developing Topics section of #AAIC22!

Everything you need to know about sequencing education.knoweng.org/sequenceng/# An interactive learning resource for next-generation sequencing (NGS) techniques

Very excited that the second paper from my PhD is now on biorxiv! If you are interested in spinal cord, postnatal development, and microglial, have a read and let me now what you think! Many thanks to Dale Moulding, Wenanlan and @SimonBeggsLab biorxiv.org/content/10.110…

Pleased to share this first-author review, out now in Molecular Neurodegeneration! 'The era of cryptic exons: implications for ALS-FTD' We discuss recent discoveries & the exciting opportunities that cryptic exons offer for the development of novel therapies & biomarkers in #ALS #MND #FTD 🧠🧪

🚨New paper alert!🚨 Neonatal pain can sensitize you for life, leading to hyperalgesia upon re-injury in adulthood. 👶🩹 Why does this happen? 🧵 TLDR: Neonatal injury causes microglia to prune synapses in the spinal cord leading to long-term reduction of inhibitory synapses 1/9

BTR: A Bioinformatics Tool Recommendation System biorxiv.org/content/10.110… github.com/ryangreenj/bio…

Check out our new work on cryptic peptides in ALS/FTD!

After seven (7!) years of work with >20 researchers at 10 different institutions, we are super excited to release NextBrain, a next-gen probabilistic atlas of the human brain with 333 regions: github-pages.ucl.ac.uk/NextBrain Preprint, data, code, videos, and much more in this 🧵(1/5)

Honoured & humbled to have won this Royal College of Physicians prize! Thank you to Pietro Fratta FrattaLab & Marc-David Ruepp Ruepp Lab for their ongoing supervision & mentorship during my PhD.

This fMRI technique promised to transform brain research — why can no one replicate it? nature.com/articles/d4158…

Hacking the immune system could slow ageing — here’s how nature.com/articles/d4158…

An academic career progression can be perfectly linear: PhD - Postdoc - Assistant Professor. Here’s mine: PhD - Postdoc 1 - Postdoc 2 - Postdoc 3 - Instructor - Senior Postdoc - Scientist II - Scientific Director - Assistant Professor. And you know what? That’s ok. AMA ;)

To all PhDs & Postdocs: A great review paper can change your academic career. I'll show you the 20 steps that transformed mine.

1. Honest title of every transcription talk: “everything we previously told you about transcription was wrong, again” Honest title of every cell division talk: “here are 3 more proteins that are apparently absolutely essential for cell division but no one worked on previously”

There are six biotypes of depression. 🧵1/10

Molecular cloning: a ubiquitous and essential molecular biology technique. It's also the reason many scientists become superstitious, some equating cloning to witchcraft. But why, and does it have to be this way?

Muscles 💪 and AAV 🦠 - what more could you ask for? Our preprint highlighting strategies for effective transduction of skeletal muscle with AAV with Wenanlan @J_N_Slayer FrattaLab : biorxiv.org/content/10.110… UCL Queen Square Institute of Neurology UCL Brain Sciences UCL Div of Surgery The Crick UK Dementia Research Institute