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Looking forward to being there

Acetylation of H3K115 at the nucleosome dyad is associated with fragile nucleosomes at active regulatory sites. Lovely work from Yatendra Kumar Dipta Sengupta Robert Illingworth @EliasFriman MRC_HGU Institute of Genetics and Cancer biorxiv.org/content/10.110…

Take a first step to your career in Genetics, Genomics and Disease by applying to our 4 year PhD programme. UK and International applicants welcome. Deadline 17/1/2024 ed.ac.uk/mrc-human-gene…

Variant to function: are footprints and eRNAs the best pointer to functional non-coding genetic variants? MRC_HGU Institute of Genetics and Cancer Simon Biddie @EliasFriman Giovanna Weykopf biorxiv.org/content/10.110…

We are hiring! Please RT We are recruiting a new Bioinformatics Core Manager for the Institute of Genetics and Cancer, University of Edinburgh: ed.ac.uk/medicine-vet-m… The next step in your bioinformatics career! Apply before 17th January 2024: elxw.fa.em3.oraclecloud.com/hcmUI/Candidat…

🥛📈 New and disruptive scientific knowledge is fostered by being under one roof, sharing the same coffee room. nature.com/articles/s4158…

Exciting demonstration of the value of deep WGS, and calling of structural variants, for effective patient stratification

I've just signed the petition opposing plans to build a destructive luxury golf course at beautiful rugged #CoulLinks in the #ScottishHighlands. Will you sign too? #BeautifulScotland you.38degrees.org.uk/petitions/save… via 38 Degrees

The full line-up of speakers for the Mutations in Time and Space conference is now available. You can still register- head over to mutationmeeting.com before 21st of March.

Director of MRC_HGU Wendy Bickmore opens the session on research developments in rare diseases at Genetic Alliance UK’s Scotland Rare Disease Day Reception at the Institute today. #RareDiseaseDay2024 #RareDiseaseDay

An inspirational event that brought together a diverse set of voices to discuss the challenges, progress and opportunities associated with rare disease.

Very happy we are now able to share this, and thanks to everyone who contributed! We hope that this will be useful for developers and users of variant effect predictors. See also our big list of VEPs at varianteffect.org/veps

Our preprint on the role of the nuclear pore protein TPR in cytoplasmic chromatin formation in senescence is out! This is most of the work from my PhD, so seeing it out in the world is a proud moment for me. biorxiv.org/content/10.110… Here’s a brief summary of our key results:

Our latest VEP benchmarking study is out now, with an improved methodology, new top-ranking methods, and showing that relative performance against DMS/MAVE assays is highly reflective of relative performance in clinical variant classification Ben Livesey biorxiv.org/content/10.110…

Congratulations to Professor Yanick Crow on his election to the Royal Society in recognition of his work on human genetic disease @crow_lab MRC_HGU ed.ac.uk/institute-gene…

Just published in PLOS Genetics. Luciana Gómez Acuña @EliasFriman Ilya Flyamer 💙💛 show surprising differences in what 3C- and imaging-based methods tell us about enhancer-promoter communication. MRC_HGU Institute of Genetics and Cancer journals.plos.org/plosgenetics/a… ed.ac.uk/institute-gene…

You will note that I have been pretty quiet on X of late. I am moving to BlueSky, where you can find me @wbickmor.bsky.social

If you want to find out about our latest work on enhancer function and 3D genome organisation, check it out at: bsky.app/profile/wbickm… .. and its bye-bye from me on this platform. Join me @wbickmor.bsky.social