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Nice article summarising use cases for ctDNA & how to interpret in real world clinical practice nature.com/articles/s4158…

🚨 It’s a pleasure to announce I will be starting my own group later this year Early Cancer Institute, University of Cambridge CRUK Cambridge Centre! We’ll be leveraging non-invasive samples, e.g. ctDNA, to monitor somatic evolution. Please get in touch if you’d like to join me on this exciting new journey!

Today on the blog 🌍📣: The 1st of a 4-part series featuring the authors of this groundbreaking research featured in nature. "Our study has fundamentally changed how we view lung cancer in never smokers." Charles Swanton Will Hill Emilia Lim Clare Weeden Tourism CU Cancer Center

Subcutaneous atezolizumab (as opposed to IV therapy) is approved in the UK by the MHRA. It’s faster delivery for patients and reduces the increasing burden on systemic therapy units in cancer centres. It’s particularly relevant in the adjuvant setting. england.nhs.uk/2023/08/nhs-wo…

Great to attend the #AGNC2023 meeting today and to discuss the clinical insights into lung cancer from the #TRACERX and #PEACE studies. Thank you for having me AGNC Vishakha Tripathi

Beautiful TRACERx update correlating tumour met velocity with ctDNA changes and seeding subclones #ESMO23 very well presented by Wing Kin Liu

Wonderful summary of TRACERx latest data by Prof Mitsudomi reviewing ⁦Crispin Hiley⁩ ⁦Sonya Hessey⁩ and Wing Liu work - Clonal TMB , metastasis growth rates and Immune evasion mechanisms - thanks ⁦The Crick⁩ ⁦UCL Cancer Institute⁩ ⁦CRUK Manchester Institute⁩ Science and Innovation at Cancer Research UK⁩

Enfortumab vedotin & Pembrolizumab improving PFS & OS by 55% & 53% respectively compared to platinum based chemo in 1st line UC (+avelumab in 30%). Chemo has not been beaten before (despite multiple efforts). RR and CR of 68% & 29% is hard to beat. DOR not reached (1/3)#ESMO2023

Really enjoyed #ESMO2023. Thrilled to present recent work from TRACERx & PEACE showing genetic immune evasion alterations are heterogeneous across NSCLC mets. Thanks to Charles Swanton, @MariamJHanjani and #CRUK. Congrats to Crispin Hiley Wing Kin Liu Yin Wu James Black

We're absolutely over the moon that Tom Powles is included in nature 's global list of ‘the 10 people who shaped science in 2023’. His work on new treatment for #bladdercancer was recognised as a world-class contribution to science. Congratulations! qmul.ac.uk/media/news/202…

📣Liquid Biopsy Response Evaluation Criteria in Solid Tumors (LB-RECIST) Annals of Oncology ESMO - Eur. Oncology ➡️ctDNA ➡️For now, plasma should be used. But in future, disease-specific sample may be used (urine, bile) ➡️In metastatic setting, used to evaluate the response. In earlier

Enfortumab + Pembro outperforms platinum chemotherapy in advanced UC with a doubling of PFS and a halving of the risk of death @nejm. G3/4 AEs of 56% for EVP vs 70% for chemo & CR=29%. Editorial by @gniegisch ‘EVP is the new standard against which future trials must be compared’

Life lessons from Roger Federer (must watch) 1 Effortless is a myth 2 Belief in yourself has to be earned 3 Grit > Gift 4 Discipline is talent 5 Trust and loving the process is talent 6 You can do your best and still lose 7 Life is bigger than the court

Hi everyone, I will be running the Royal Parks half marathon to raise money for Cure Cancer. We are aiming to buy a new flow cytometer for the UCL Cancer Institute. Please donate if you can, every little helps! Cure Cancer at Ucl Cancer Institute UCL Cancer Institute Royal Parks Half app.goodhub.com/cure-cancer-at…

Writing a scientific article: A step-by-step guide for beginners (1/7)

Unexpected and slightly overwhelming news from UCL Faculty of Medical Sciences. I am extremely grateful to Science and Innovation at Cancer Research UK for their constant support and most importantly the incredible scientists UCL Cancer Institute past and present who made this happen. A privilege to stand on the shoulders of giants.

heatmap in ggplot2 yunuuuu.github.io/ggalign/articl… I always use complexheatmap, but this seems to be a good alternative if you want to stay within the ggplot. #rstats

Gael Monfils & Giovanni Mpetshi Perricard cooling down together after their match at Australian Open 3 hours & 45 minute match Brutal 5 setter But when it’s over, there are no winners or losers Just 2 friends riding their bikes, having a chat 🚲 🚲

Had a great time presenting my poster on the ctDNA transformation pilot for patients with advanced NSCLC in South East England at the BTOG conference. Hope to be back next year! #btog #nhsengland #ctdna