Very excited to share our recent work with amazing collaborators @EloiseGrasset and Andy Ewald showing key spatial relationships between metastasis-initiating cancer cells and macrophage subtypes! hopkinsmedicine.org/news/newsroom/… nature.com/articles/s4138…

incredible work led by Dimitri Sidiropoulos to peruse through the TLS forming in PDAC - a great show of making the most of multiple state-of-the-art tools to synthesize our understanding

Awakening the tumor immune microenvironment. Strategy from Nicole Gross, Zhehao Zhang et al. enhances antitumor efficacy for immune-resistant pancreatic cancer. @WonJinHo1 Johns Hopkins Medicine

In light of the negative #IMbrave050 study (no benefit w/ adj atezo+bev), a timely study by Mari Nakazawa supporting neoadj ICI (NI) ⏩doi.org/10.1158/2767-9… ⏩NI may allow pts outside of traditional resection criteria to achieve long term survival ⏩Prospective trials warranted!

1/Excited to share our latest research led by Chester Kao & Soren Charmsaz , published in Journal of Clinical Investigation! ➡️We found that immune-related adverse events (irAEs) in patients receiving IO are linked to Th17 and Th2 signatures jci.org/articles/view/…

A seminar to look forward to

Just spectacular work by @DanielShuMD

It's wonderful to see that spatial proteomics has been recognized as Nature Methods' Method of the Year 2024. nature.com/articles/s4159…

High parameter spatial biology has grown into a standard approach in biological research. Really amazing to see the widespread recognition and take part in the adoption of this method!

Congratulations to Mark Yarchoan for winning the 2025 Blue Faery Award for Excellence in #LiverCancer #Research! #nonprofit #oncology vist.ly/3mzcgsn

1/ Excited to share our study (rdcu.be/eiAyr) published today in Nature Communications led by Chester Kao, Soren Charmsaz, and Hua-Ling Tsai evaluating age-related differences in immune responses in patients with cancer treated with immune checkpoint inhibitors (ICIs).

New cross species study examining #PancreaticCancer precursors in Journal of Clinical Investigation from Dr. Neeha Zaidi Won Jin Ho Dr. Elizabeth Jaffee Johns Hopkins Kimmel Cancer Center Spatial Proteomics and Transcriptomics Reveal Early Immune Cell Organization in Pancreatic Intraepithelial Neoplasia insight.jci.org/articles/view/…

youtube.com/watch?v=CLwcYQ…

My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15