“`In the midst of every crisis, lies great opportunity.' …we can focus more on the real objective of structural biology: to understand or influence function, mechanism, activity, binding interactions, etc. using structural information (& other biophysical and comp. methods). “

6DUY: Crystal structure of the alpha-N-catenin actin-binding domain H1 mutant rcsb.org/structure/6DUY

In 2018, I started my journey at Rommie Amaro's lab working on mesoscale simulations of influenza virus. After ~5 years in the making, I'm happy to share that the paper is now published in ACS Central Science! pubs.acs.org/doi/full/10.10… Instead of a 🧵, I made a trailer 🎞️🎥! Sound ON 🔊

I’m definitely a “Time-bender”: Why some people are always late bbc.co.uk/ideas/videos/w… via BBC Ideas💡

New preprint publication on ElasticBLAST, a cloud native application that performs #BLAST searches for a few to millions of query sequences in the Cloud! ow.ly/nScr50Mjwpw

The approval of an antibody therapy that pauses the progression of type 1 diabetes is a first in the field, and some say a model for other drug developers go.nature.com/3K5SUYB

New on BioRxiv: The essential adherens junction mechanosensitive component alpha-catenin is required for cytokinesis fidelity. We also credential a previously defined (but poorly understood) abscission factor in this process, LZTS2.

Here is how you can add protein structures from PyMOL as interactive 3D models in PowerPoint: 1) In PyMOL, export VRML2 file. 2) Convert file from VRML2 to glTF format in Blender. 3) Insert as 3D model in PowerPoint. That's it! For more info: youtu.be/0DOZ0jj289k

bbc.com/news/world-aus…

🎉 New formula Coot 1.1.09 in Brewsci/bio for Linux and macOS! ℹ️ Crystallographic Object-Oriented Toolkit 🍺 brew install brewsci/bio/coot #Bioinformatics

OPIG DPhil student Gemma Gordon led work to build and analyse "PLAbDab-nano: a database of camelid and shark nanobodies from patents and the literature". Just released on bioRxiv and available as an OPIG webapp: Preprint: biorxiv.org/content/10.110… Webapp: opig.stats.ox.ac.uk/webapps/plabda…

How Jim Carrey helped Raptors icon DeMar DeRozan face depression thestar.com/sports/raptors… via Toronto Star

There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :) bioicons.com/pdb2vector/

In Journal of Cell Biology, Wang, Yemelyanov et al. Gottardi Lab Northwestern Medicine find that the force-sensitive cell-cell #adhesion component alpha-catenin is required for #cytokinesis fidelity through LZTS2. hubs.la/Q031WQmd0 Princess Margaret Cancer Centre Research Noboru Ishiyama gingraslab #CellDivision

Wang, Yemelyanov et al. Gottardi Lab Northwestern Medicine find that the force-sensitive cell-cell #adhesion component alpha-catenin is required for #cytokinesis fidelity through LZTS2. hubs.la/Q031WKcm0 Princess Margaret Cancer Centre Research Noboru Ishiyama gingraslab #CellDivision

AT LONG LAST… The essential #adherensjunction mechanosensitive protein alpha-catenin is required for #cytokinesis fidelity. We credential a previously defined (but poorly understood) abscission factor in this process, LZTS2. 🧵1/12 rupress.org/jcb/article-ab…

Servier bags a Black Diamond in the rough. My quick take on today's $BDTX deal via ApexOnco oncologypipeline.com/apexonco/servi…