Check out our latest work on structural variation patterns in castration-resistant prostate cancer. Collab with Srinivas Viswanathan #matthewmeyerson #maryellentaplin Fred Hutch Cancer Center Dana-Farber

Happy that, on this numerically special Tuesday (2/22/22!), our work with Peter Choi on PRMT1 as a vulnerability in prostate cancer is published in Cell Reports: cell.com/cell-reports/f… #prostatecancer #pcsm @CaP_Pubs A 🧵 (-2/7)

The latest Jay Gertz preprint was just posted. It was a great group effort led by Matt Ginley with help from Xiaoyang Zhang lab and John Lis’ lab. In this study, we explored how regulatory elements influence gene expression timing and noise in response to estrogen 1/

Out nature today! Excited to finally share our work led by Juliann Shih in collab w/ Rameen Beroukhim. Our algorithm “BISCUT” looks at large chromosomal changes and aneuploidy in cancer to detect genes that can account for effects on cellular fitness. nature.com/articles/s4158…

Happy to share our latest collaborative preprint with CZ Zhang lab. We studied Xp11 translocation renal cell carcinoma (tRCC) – a rare kidney cancer – as a window into understanding how chrX alterations may drive sex differences in cancer. Thread 👇 1/ biorxiv.org/content/10.110…

how did long DNA molecules - 100 times longer than those usually sequenced in cancer - help us solve a paradox about BRCA deficiency? read all about in our paper, out in nature today nature.com/articles/s4158… 👇🧵 1/

Ever wondered how transposable elements are used differently across development and towards oncogenesis - We provide insights on their role as regulatory elements across pluripotent, mature and cancer cells, with a focus on prostate cancer: aacrjournals.org/cancerdiscover…

1/ Thrilled to share our work is out in Science Translational Medicine! TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence | Science Translational Medicine science.org/doi/10.1126/sc… Thanks the support from Dana-Farber 伊藤佑愛!

So excited to share our work on tumor genomes of African ancestry in common cancers. We report several actionable associations, including a novel ancestry-smoking interaction impacts TP53 rate. More discoveries to come if we improve diversity in genomics! cell.com/cancer-cell/fu…

Excited to share my doctoral work on amplification of the NKX2-1 lineage oncogene in lung adenocarcinoma! This work has been a real labor of love with me and the (twitter less!) Matthew Meyerson, so check it out! Tweetorial to follow 1/ biorxiv.org/content/10.110…

out today in Nature Genetics 🎉!!! our study applying a simple physical principle (mass balance) to deconstruct the notion that you need long reads to detect large variants in cancer nature.com/articles/s4158… 1/🧶

If you’re coming to #DiscoverBMB, please join Castaneda Lab and us for an interest group on phase separation/condensates and cell signaling. Fantastic speaker lineup! 👇

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells dlvr.it/T1m3YD

The Berger lab is hiring! We have openings for post-docs and research techs right now! Feel free to apply or just reach out to chat. Our lab uses functional genomics to map cancer genotype to phenotype at scale. Come join us! Links in thread

Our work on how enhancers impact estrogen transcription timing and noise is now out in Cell Genomics! Thanks to everyone that helped out on this project! cell.com/cell-genomics/… Matt Ginley Xiaoyang Zhang

Very happy to see this story published. Congratulations to Ansley and A who co-led the study. Thank you to everyone involved. A great collaboration with Livia Garzia, Veena Sangwan, Lorenzo Ferri MD PhD and Xiaoyang Zhang. aacrjournals.org/cancerres/arti…

The 3D genome organization of one of the most comprehensively characterized advanced prostate cancer cohort is now public. Phenomenal collaboration with the teams from Felix Feng @David_A_Quigley. Congrats to Shuang G for leading the effort. nature.com/articles/s4158…

We thank NCI for supporting our work in 3D cancer genomics! This work was led by our grad student Katie Mortenson, co-supervised by K-T Varley, with close collaborations from Yang Liu, Jay Gertz , and Swneke Bailey.

Happy to share our latest work published in Cancer Discovery led by Mei Luo Jingwen Yang! Great collaboration with @NCIEytanRuppin Gordon Mills! IU Simon Comprehensive Cancer Center Biostatistics & Health Data Science IUSM iubioinfo