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Lysosomal acidification is key for cellular health, w/ impairment linked to aging & neurodegenerative disease. Lin et al identify USP45 as a negative regulator of #autophagy, inhibiting V-ATPase localization to autolysosomes via Coronin 1B-actin modulation hubs.la/Q03bjMk-0

Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level Cell cell.com/cell/fulltext/…

Want to attend the HCV-Flavi symposium and also to visit the beautiful Singapore? #flavivirus #dengue #zika #arbovirus hcv-flavi2025.org

Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks #NBTNV go.nature.com/3WOWHjb rdcu.be/dItUy

🚨 New paper in Nature! MFSD6 is an entry receptor for enterovirus D68. Proud to have contributed to this work, led by brilliant co-first authors Lauren Varanese & Lily Xu. Gratitude to Jan Carette, Wah Chiu, and co-authors including Carolyn Bertozzi. 👉 nature.com/articles/s4158…

Awesome Power of Genetic Screening! Very honored to be part of this wonderful discovery—MFSD6 is an entry receptor for Enterovirus D68!

Our study on the molecular basis of shifts in receptor recognition by western equine encephalitis virus (WEEV) in the past century, led by Xiaoyi Fan and wy, is online! HMS Micro The PhD Program in Virology at HMS 🥳🥳🥳cell.com/cell/fulltext/…

science.org/doi/abs/10.112…

“I’ve never thought that this would be accomplished in my lifetime” Researchers have successfully sequenced the complete genomes of six ape species go.nature.com/4lpDn5Q

Precise DNA integration is key for many therapies, but inserting large, scarless sequences remains challenging. What if we could reprogram nature's mobile elements for programmable genome writing? Today we (+ Omar Abudayyeh) debut Stitchr in nature

Out Now! Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence bit.ly/4jebHzK #Microbiology #Antimicrobial #Bacteria

The gene editing tool STITCHR contains an R2 retrotransposon fused to a CRISPR–Cas9 nickase to install diverse edits, including multi-kilobase insertions, in vitro. nature.com/articles/s4158… #NBTHighlight

SAMD9 senses cytosolic double-stranded nucleic acids in epithelial and mesenchymal cells to induce antiviral immunity Nature Communications Siyuan Ding Gaopeng Hou nature.com/articles/s4146…

Curve the way for the RNA virus replication complex to work. #Chikungunya #virus "Saddle Curvature Association of nsP1 Facilitates the Replication Complex Assembly of Chikungunya Virus in Cells" biorxiv.org/content/10.110…

How to find fantastic new #RNAs? The J2 antibody is the gold standard to detect, map & enrich dsRNAs. Co-led by Bou-Nader lab, Kevin Juma, Ankur Bothra & Steve Leppla’s lab, we visualize how J2 recognizes dsRNA and define its epitope, specificity & bias. doi.org/10.1101/2025.0….

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

Thrilled to announce our Phase Separation AI & Systems Biology platform, PhaseHub, is live today! 😀 Explore your favorite protein complexes for "Signaling Hub" hunting—dive in now! From Pan-Life Phase Insights to PhaseHub: Analyzing Condensate Complexity biorxiv.org/content/10.110…

A team of scientists from #dukenus and Yong Loo Lin School of Medicine has developed a test to help tackle the next pandemic, now in more than 90 countries. Read more about it at straitstimes.com/singapore/heal… #DukeNUS #Research #PandemicPreparedness

New online! Evolution, spread and impact of highly pathogenic H5 avian influenza A viruses nature.com/articles/s4157…