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We are thrilled to share our new work published in Nature today reporting a long-sought peroxisomal retrotranslocation channel formed by a ubiquitin ligase complex. Phenomenal work by our postdocs Peiqiang Feng, Xudong Wu and collaborators. nature.com/articles/s4158…

One of the coolest mechanisms we’ve worked on: rdcu.be/cSPbR Matthew Yip and @samanthasedor reveal how the hybrid E2/E3 enzyme UBE2O, which ubiquitinates unassembled ribosomal proteins for degradation, selects its clients.

Structures of BIRC6-Client Complexes Provide Mechanism of Smac-Mediated Release of Caspases biorxiv.org/cgi/content/sh…

Thrilled to share my first paper from grad school out today in Mol Cell! I am incredibly grateful to the Elledge lab and my wonderful collaborators/friends, without them this work would not have been possible. cell.com/molecular-cell…