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MDA5 is a key sensor of viral dsRNA. In the latest issue of JBC, Singh et al. show that cofactor LGP2 nucleates MDA5 filaments at internal sites on dsRNA in an ATP-dependent manner. Learn more & explore the issue: jbc.org/issue/S0021-92…. #ASBMBJournals #OpenAccess #PeerReviewed

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

Broad-spectrum activity against mosquito-borne flaviviruses achieved by targeting protein degradation Stanford Medicine #dengue #virology #antivirals nature.com/articles/s4146…

We are delighted to announce that Professor Edith Heard has been appointed as our new director and chief executive! Edith, who is currently director-general at @EMBL, will succeed Paul Nurse in leading the Crick from the summer of 2025. 🔗 crick.ac.uk/news/2024-07-0…

🚨 Job Opportunity: Research Associate (Fixed Term) to study host-pathogen interactions and innate immune recognition with Prof Yorgo Modis The group is part of the Molecular Immunity Unit in the @MRC_LMB ➡️bit.ly/3RR0aKQ Close: 28 July 2024 #jobs | #research | #CITIID

Competition between two HUSH complexes orchestrates the immune response to retroelement invasion doi.org/10.1016/j.molc…

Nature research paper: A eukaryotic-like ubiquitination system in bacterial antiviral defence go.nature.com/3SzNqc7

Looking for a postdoctoral research scientist with prior experience in cryo-EM to study virus-host interactions and coevolution in our group. We benefit from a great environment @MRC_LMB Medicine at Cambridge Cambridge University Apply by 28th July jobs.cam.ac.uk/job/46301/

Nature research paper: The hepatitis C virus envelope protein complex is a dimer of heterodimers go.nature.com/4gdmRDx

This is awesome 👇

Beautiful work on Alphavirus replication vasiliya kril @amara_lab Juan Reguera

Are you interested in doing a PhD Cambridge University? Why don’t you come to my lab to study the role of long non-coding RNAs 🧬 during Zika virus 🦠 infection? We have a 4-year funded PhD studentship!!! Deadline: 7 Jan 2025 (UK-students only) findaphd.com/phds/project/f…

I will no longer be posting on this platform. In my opinion another Trump presidency would be damaging to the US and the world. This platform's owner is now too closely aligned to Trump for me to feel comfortable here.

Looking for an Assistant Teaching Professor and Course Director of the MPhil in Translational Medical Research at Cambridge. The role is to run academic and research components of the MPhil, and develop teaching and scholarship Medicine at Cambridge Cambridge Biomedical Campus jobs.cam.ac.uk/job/51441/

Our latest paper is out on MDA5 variants that increase risk of chronic inflammation but protect from autoimmune disease. Work from a fantastic team shows these variants dampen the antiviral response via loss of RNA binding & increased ATPase activity. cell.com/cell-reports/f…

Another paper out on MDA5: our GWAS meta-analysis shows loss-of-function variants protect vs multiple autoimmune diseases but IBD increase disease risk. So genetic variants offer a fitness tradeoff between viral clearance & autoimmune tissue damage. doi.org/10.1186/s12920…

Looking for a fully-funded D. Phil. / Ph.D. studentship in structural biology and vaccinology? Come to join our team. Fully and generously funded by a donation from the Kyner-Field family with full fees at overseas level. Join us?? bioch.ox.ac.uk/studentships