SH2 domains thought of as "undruggable" - A News & Views by Oliver Hantschel highlights recent work from Alessio Ciulli lab Nature Communications on an inhibitor of the SH2 domain of E3 ligase SOCS2. Read it here rdcu.be/dyPR9 and the original article rdcu.be/dyPR0

How does DNA damage signaling suppress chromosomal rearrangements? Check our recent paper just out in EMBO Journal. Multi-step control of homologous recombination via Mec1/ATR suppresses chromosomal rearrangements | embopress.org/doi/full/10.10…

Check out this thoughtful Preview from Billy on our recent manuscript in Molecular Cell. Thanks Billy!

Excited to share our preprint reporting a completely new approach to study kinase signaling (ProKAS): "Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling" We applied it to DDR kinases. Please share. biorxiv.org/content/10.110…

Very excited to share our new paper out in nature today, led by my amazing postdoc, Qingfei Zheng (now at Purdue University) in collab w/ The Maze Lab (with Li & The Muir Lab) showing a beautiful mechanism of monoamine modification swapping in neurons 🤩 rdcu.be/d5CNc

Paper published during postdoc just reached 1000 citations.