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Dissecting the temporal code of neural differentiation. Great work by Anat Kreimer 💔, @TalAshuach, Taka Inoue and Yosef Lab! Massively parallel reporter perturbation assay uncovers temporal regulatory architecture during neural… disq.us/t/3vi4q54

CliP: subclonal architecture reconstruction of cancer cells in DNA sequencing data using a penalized likelihood model biorxiv.org/content/10.110…

nature.com/articles/s4159… Glad to share our recent work SnapHiC, a method to call loops from single cell Hi-C data. Great collaboration with Dr. Bing Ren and Dr. Yun Li Yun Li

CRISPRpath is out today! science.org/doi/10.1126/sc… Congratulations to our talented postdoc @xingjie_ren! I feel lucky to work with many great collaborators, including Yun Li, Ming Hu, Bing Ren, and Wei Wang at UCSD.

If you are interested in 3D genome and single cell genomics, please join our team. Here is the postdoc job AD: sites.google.com/site/afhuming/…. Please RT.

‘The numbers are pretty appalling’: Asian scientists rarely awarded top scientific prizes statnews.com/2022/02/03/sci… via STAT

AddThis | Home authors.elsevier.com/a/1etHYcQbJ3ia… Glad to share our recent forum about single cell Hi-C in Trends in Genetics Great collaboration with Dr. Miao Yu and Yun Li

Integrative analysis of the 3D genome and epigenome in mouse embryonic tissues biorxiv.org/content/10.110… Glad to share our recent preprint. Great collaboration with Dr. Bing Ren.

Our work that carefully evaluated Hi-C data enhancement methods for enhancing PLAC-seq and HiChIP data: academic.oup.com/bib/advance-ar… Always enjoyed collaboration with Ming Hu

I'm very pleasured to announce the publication of our TOP-LD: cell.com/ajhg/fulltext/…. A handy and fast query to search LD information across multiple populations using TOPMed WGS data: topld.genetics.unc.edu Great collaboration with Paul Auer

I’m excited to share our latest preprint, in which we explore the relationship between enhancers, 3D chromatin structure, and transcription during macrophage activation! 🧵

Excited to share Euphy Wu's @FennecPaaaw 1st preprint from the lab: SEESAW, a method to detect isoform-level allelic imbalance from RNA-seq while accounting for uncertainty, a collaboration with 𝕐 and his group, as well as others along the way. biorxiv.org/content/10.110…

We are thrilled to announce PRIME, a game-changing high-throughput method for characterizing DNA sequences with all possible nucleotide substitutions. We had great collaborations with Elad Ziv Yun Li. Congratulations to the first authors @xingjie_ren and Han Yang!

Very pround to be part of the excellent team presenting PRIME, a game-changing high-throughput method for characterizing DNA sequences with all possible nucleotide substitutions. Enjoyed working with Yin Shen Elad Ziv Xingjie Ren and Han Yang !

We are excited to share our work on genome-scale functional characterization of candidate cis-regulatory elements (cCREs) in iPSCs and during neuronal differentiation, funded by ENCODE Project and 4DNucleome biorxiv.org/content/10.110… 1/11

I am thrilled to share our variant-to-function study for Alzheimer's disease in microglia: online today Nature Genetics. Wonderful collaboration with Yin Shen! Thanks also to Gan Lab

We are delighted that our PRIME method found its home Molecular Cell. The cover art is exquisitely designed by the leader behind the PRIME development Xingjie Ren. Congratulations to Xingjie Ren Han Yang and the entire team! authors.elsevier.com/sd/article/S10…

Proud to be part of the team presenting the PRIMED method for high throughput, base pair resolution editing! Beautiful cover with Molecular Cell Congratulations to Yin Shen

nature.com/articles/s4158… I am very excited to share our recent paper on nature . It is a great collaboration with Dr. Murre and Dr. Fisch at UCSD. We discovered a molecular mechanism to shape nuclear morphology. Cleveland Clinic Lerner Research Institute

Our UNC CompMed Program has a new open-rank faculty position open.