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Another awesome Pew mtg in the books. What a privilege! So happy to have met new people and to reconnect with others 💕 Pew is an amazing community 🧡 Excited for the connections that started in these meetings #LatinAmericanFellow Onwards! 💪🏾💕👩🏽‍🔬

Excited to share our latest review describing Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation The Colonna Lab - Immunological Reviews - Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11…

NEW Review of the molecular mechanisms by which short-chain fatty acids - butyrate, propionate and acetate - link diet, microbiota and immunity bit.ly/49jfypn by Lizzie Mann UoM Ying Ka Lam & Holm Uhlig

Deficiency of IL-22–binding protein enhances the ability of the gut microbiota to protect against enteric pathogens The Colonna Lab Blanda Di Luccia José Fachi, PhD pnas.org/doi/10.1073/pn…

#WeekendRead! The Colonna Lab & #IL22 are on🔥! Siyan Cao "Stewart", MD PhD &co show Journal of Clinical Investigation that ER stress control IL22 in ILC3s in #IBD jci.org/articles/view/…! Blanda Di Luccia José Fachi, PhD &co show PNASNews that lacking IL22BP reshape the #microbiota against gut infection pnas.org/doi/10.1073/pn…

📢Come join us this Thursday! We'll discuss fellowship applications (both grad and postdoc) as an #InternationalTrainee in the US. If you are transitioning to a postdoc, this talk may help you prepare ahead ;) Yale Cell Biology Yale Neuroscience Yale Postdoctoral Association (YPA) 📅05/16 ⏲️3pm

It was an honor to attend the Tsinghua-RIKEN International Summer Program in Beijing, China, and be part of the class of 2024. The experience included inspiring speakers from around the world and the formation of lifelong friendships.

Happy to share our new study showing IL-22BP deficiency enhances gut microbiota's defense against infections. This boosts acetate production by Il22ra2–/–associated microbiota, suggesting IL-22BP as a therapeutic target. Led by José Fachi, PhD and Blanda Di Luccia pnas.org/doi/10.1073/pn…

Our new paper led by Tihana Trsan, collaboration with Xavier Lab, investigating the link between FGFR1OP and Crohn’s disease. Deletion of FGFR1OP, a centrosomal protein, in mouse gut cells disrupts crypt architecture, causing inflammation and fatality cell.com/developmental-…

.Siyan Cao "Stewart", MD PhD et al. from the The Colonna Lab Test Account show that the IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease: buff.ly/3W7heyJ #Gastroenterology #Immunology

cat losing his day job 😹

Our work by Fachi et al. José Fachi, PhD is out in PNAS! We show how NKp46+ ILC3s boost early gut defense against C. difficile infection by producing GM-CSF to support neutrophils. A potential path to new CDI treatments! pnas.org/doi/10.1073/pn…

Our new paper in Cell Host & Microbe: Low-fiber diets worsen C. difficile infection by increasing epithelial MHC-II and expanding pathogenic CD4+ IELs. Fiber-derived acetate and FFAR2 boost ILC3 IL-22, suppressing colonic MHC-II and aiding recovery. authors.elsevier.com/sd/article/S19…

A study from Victora Lab and DM in Science Magazine reveals how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of both food allergies and intestinal diseases. #RockefellerScience bit.ly/4hyS18b

Fiber fine tunes MHC to impact CDI Low-fiber diet worsens C. difficile infection by increasing MHC-II in colonic epithelium, promoting pathogenic CD4+IELs. Acetate from fibers enhances ILC3-derived IL-22, suppressing MHC-II expression The Colonna Lab cell.com/cell-host-micr…

Excited to share that our work is featured on the cover of the latest issue of Cell Host & Microbe! Check it out! The Colonna Lab Marco Vinolo The Pew Trusts #Microbiology #Immunology #CellHostMicrobe

Estudo sugere que consumo de #fibras protege o #intestino contra infecção bacteriana grave. Roedores alimentados com dieta rica em fibras solúveis lidaram melhor com microrganismo que causa diarreia e pode levar pacientes debilitados à morte. agencia.fapesp.br/54030

OBS #Immunology Seminar ILC3 📆 Thu, 27th March , 9 am PDT, 12 pm EDT 🎙️@zefachi@TheColonnaLab 🎙️ Leandro Pires Araújo -Ivaylo I. Ivanov Lab 📣 Moderator @eugeccc Registration us02web.zoom.us/meeting/regist…

Excited to share that our work by Patrick Rodrigues and Tong Wu is published in Cell: RORγt+ DCs are required to induce oral tolerance. Their absence reduces pTregs and impairs oral tolerance to dietary antigens. Read more: authors.elsevier.com/sd/article/S00…

José Fachi, PhD talk is now on YouTube! 🎙️ José Luis Fachi (Washington University in St. Louis l) 📣 NKp46+ ILC3s promote early neutrophil defense against Clostridioides difficile infection through GM-CSF secretion (PNAS, 20254) youtu.be/wEaptMNfNw0