Researchers Tomas Zelenka Babis Spilianakis part of @IMBB_FORTH Marie Skłodowska-Curie Actions Marie Curie Alumni Association (MCAA) show SATB1, a predominantly T-cell specific protein, helps to establish a regulatory, finer-scale 3D organizational layer on top of pre-existing chromatin scaffolds. go.nature.com/3F5M2aK

Great paper. I strongly agree that causal gene regulatory network inference (i.e. where u can actually claim gene A causally and directly regulates gene B) using mRNA alone is impossible IMHO. Even from perturbation expts. I think this is impossible. 1/

Our work using single-molecule chromatin configurations to link TF binding to gene expression is now out on bioRxiv! Amazing effort from Benjamin Doughty, Michaela Hinks, and juliaschaepe, and an immensely rewarding collaboration with the Bintu Lab: biorxiv.org/content/10.110… [1/n]

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