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Previously, we showed that when C. elegans is exposed to and ingests PA14 for 24hrs, not only do these worms learn to avoid the bacteria, but their progeny – through the F4 generation – inherit this learned avoidance doi.org/10.1016/j.cell…

Will post a longer thread soon but couldn't wait to share! Happy to chat with anyone about using M3-Seq for all your bacterial single cell sequencing needs! And thanks to our fearless Bruce Wang for leading the charge and our amazing collaborators Britt Adamson and Ned Wingreen.

Why does Mycobacterium tuberculosis form cords? It's immediately apparent when viewing a bacterial culture growing without detergent under a microscope. Delighted to have led an interdisciplinary study to answer this puzzle (1/8) authors.elsevier.com/sd/article/S00…

I had such a blast talking with my old friend and former UCSF colleague ctmurphy1.bsky.social about her new book. Congratulations Coleen on this major accomplishment!

Story time: when I started my postdoc with Chris Waters in August last year, we aimed to use V. cholerae to understand how genetic interactions, including epistasis and pleiotropy, influences its pathogenesis and evolution. 1/18

New year, new class of antibiotic - but the old model of reimbursement will kill it unless we change course. A new class of antibiotics is cause for cautious celebration — but the economics must be fixed nature.com/articles/d4158…

Check our new preprint by Dr. Nazgul Sakenova where we advance the identification of cross-resistance & collateral sensitivity between antibiotics using chemical genetics data, uncover underlying mechanisms and use the insights to reduce resistance evolution. biorxiv.org/content/10.110…

I'm so honored to be elected a Fellow of the American Academy of Microbiology. Thank you so much to my amazing lab members, my fantastic mentors, and all you great role models. I am so lucky and thankful. Here's to our great community and to even more awesome science to come!

A cool profile of me in Current Biology sciencedirect.com/science/articl… tl;dr: I describe one of my central beliefs – the importance of taking breaks from the lab to allow for creative scientific thought.

New prepint alert @themaxwelllab! 📢 📢 📢 Superinfection exclusion (Sie) proteins aren’t just for defence – they also ensure the spread of viral progeny! Prophages that lack Sie proteins devour their young via a process we call the Kronos effect. biorxiv.org/content/10.110…

Why are some non-antibiotic drugs toxic to bacteria 💊☠️🦠? Do they work like standard #antibiotics (ABX)? Our latest work by Mariana Noto published Science Magazine addresses this fundamental question (1/n) science.org/doi/10.1126/sc…

The phiKZ jumbo phages build a protein based nucleus to protect their DNA(!), but what do they do before the nucleus is built? Led by outstanding post-doc Deepto Mozumdar, here we identify host and phage proteins in an immediate early phage lipid vesicle. biorxiv.org/content/10.110…

A big week for the lab! See terrific work by Ann Cirincione and Danny Simpson here 👇

Phages snap TFP to prevent further infection! Cool collab with labs of Lanying Zeng and Junjie Zhang TAMU BCBP, Yiruo Lin Texas A&M University, Yinghao Wu Albert Einstein College of Medicine - Official, Joshua Shaevitz and zgitai Princeton MolBio CPBF, and our lab TAMU Biology science.org/doi/10.1126/sc…

OUT NOW 📢: A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting zgitai nature.com/articles/s4156…

So excited for our latest story on a tunable-spectrum antibiotic to be published. We desperately need microbiome-sparing strategies to treat P. aeruginosa. Amazing effort led by the fantastic @ConnorChain

How to pick a problem. Today in Cell. 1/53 cell.com/cell/fulltext/…

🦠Pathogenic bacterium Pseudomonas aeruginosa breaches lung defenses by targeting mucus producing goblet cells! Intracellular P. aeruginosa may evade immune system and antibiotic treatment, thereby driving chronic infections NCCR AntiResist Institute of Human Biology doi.org/10.1038/s41564…

Just discovered that Hunter has this in review at eLife - the journal - the fact that it went out for review is concerning, given their publishing model and the amount of detective work it took to figure out why everything they did is wrong. Again, what he did has nothing to do with our work

I interrupt your election panic to announce that I, too, am an academic who cannot breakdance. Happy Halloween!