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Our recent work on reversing the enantioselectivity of carbene N–H insertion enzyme is now on Chemrxiv (chemrxiv.org/engage/chemrxi…)! A nice collaboration again with Marc Garcia-Borràs and Carla Calvó-Tusell. Check it out! Congrats to everyone 😀 Frances Arnold Kai Chen

We reversed the carbene NH insertion enzyme selectivity through mechanism-guided protein engineering! This work is now published on Angewante✌️onlinelibrary.wiley.com/doi/10.1002/an… Huge congrats to Marc Garcia-Borràs Carla Calvó-Tusell Kai Chen and Frances Arnold

After losing my account for over a year, I finally got it back with the help of Twitter Support👍 Here to share a review that my students and I wrote during this period on biocatalytic C–N bond-forming reactions: sciencedirect.com/science/articl…

After the Plenary Lecture by Prof. List (Ben List), 12 young scientists will give talks at wipos.org: T. Cernak, Muhammad Jbara, KatayevLab, Christine Le, H. Liao, Zhen, Neufeldt Lab, Cody Ross Pitts, Powers Lab, Courtney Roberts, Zach Wickens & C-X. Zhuo.

WIPOS 2024 (Dec 16-19, 2024 in Hawaii, wipos.org) will feature many speakers from academia: Søren Kramer, Lisbet Kvaerno, Sami Lakhdar, T. Luo, Ahmad Masarwa (Masarwa Lab), Joshua Pierce, X. Qi, Dr. Indrajeet Sharma, Sherburn Lab, Alex M. Szpilman, W. Tang, H. Xu, Andrei Yudin.

Now online: Article by Marc Garcia-Borràs, Zhen Liu & co-workers Zhen Marc Garcia-Borràs Carla Calvó-Tusell Biocatalytic desymmetrization for synthesis of chiral enones using flavoenzymes nature.com/articles/s4416… ($)

Stereospecific Enzymatic Conversion of Boronic Acids to Amines by Deirdre Hanley, Zi-Qi Li, Shilong (Gregg) Gao, Scott C. Virgil, Frances Arnold at Caltech Chemistry & Chemical Engineering, and Edwin Alfonzo in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Congratulations to Professor Frances Arnold (Frances Arnold) on receiving the 2025 Priestley Medal! 🎉 The ACS is honoring Arnold, "for her pioneering contributions to the development of directed evolution as a method for chemical and biological design." cce.caltech.edu/news-and-event…

Sequence-encoded monomers, a platform for translating difunctionalization into linear polymer backbones. A fun collaboration w/ Gutekunst Group Peng Liu Group & #BMSChemistry, appearing today in Nature Synthesis. tinyurl.com/mujhve56

Inspired by the abiotic functions of cytochrome P450s, a chemocatalytic platform was developed to enable direct primary amination of various C(sp3)−H bonds under air and aqueous conditions. pubs.acs.org/doi/10.1021/ja…

Nov issue live🍂 Synthesis of chiral enones using flavoenzymes Fe-catalysed π-extension Cross-hydrodimerization of alkenes Ni-catalysed dicarbofunctionalization for polymers Insight into benzylidene-directed glycosylation (Continued) nature.com/natsynth/volum…

Now online: An Editorial highlighting some of the excellent covers featured in Nature Synthesis in 2024 as well as the research they represent. Thanks to our authors for submitting such great covers! nature.com/articles/s4416…

Thrilled to share our progress on the synthesis of highly oxidized DMOA-derived meroterpenoids—now out in JACS:pubs.acs.org/doi/10.1021/ja…! The unexpected reaction we stumbled upon in the final step turned out to be especially fascinating.

Really enjoying #Repartzymes Repurposed and Artificial Enzymes meeting organized by #TomWard of Uni. Basel. Many former group members are here! rep.artzymes.info