“Hunting down the elusive cytosolic-DNA sensor,” by Diane Mathis outlines how cGAS was discovered, and the crucial findings made by Zhijian “James” Chen, winner of the 2024 Basic Research #LaskerAward. pnas.org/doi/10.1073/pn… #Lasker2024 #LaskerLaureate #UTSWMed

Check out our most recent work: Generation of a novel constitutive smooth muscle cell-specific Myh11-driven Cre mouse model | bioRxiv biorxiv.org/content/10.110…

I promised to write an end-to-end tutorial to replicate this genomics figure during the holidays. Now it is ready 👇

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 @LeopoldParts, Pierre Murat

chatomics! In this youtube playlist, I will be adding videos to reproduce a genomics paper figure youtube.com/watch?v=-UKVp_… to accompany the written tutorial crazyhottommy.github.io/reproduce_geno…

A constitutive #SmoothMuscleCell-specific Cre mice under precise control of endogenous Myh11 loci🤠 This time, we do not need to worry about off-targeting embryonic cardiomyocyte or male gamete😁 Kunzhe Dong Zhou Smooth Muscle Lab bioRxiv 2024 biorxiv.org/content/10.110…

Science never follows a simple path from A to B, but we rarely publish the story of all the branches on the open ended paths we take to get to a result

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:

The lab is hiring postdocs! Several exciting projects are waiting for you! jobs.sciencecareers.org/job/674732/pos…