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mLiftOver: Harmonizing Data Across Infinium DNA Methylation Platforms biorxiv.org/cgi/content/sh… #bioRxiv

Facing challenges with data harmonization on EPICv2? Our latest preprint introduces mLiftOver, designed for data conversion between HM27/HM450/EPIC and EPICv2, including support for the new MSA array! Details here: biorxiv.org/content/10.110… #genomics #bioinformatics

Harmonize data across different generations of Illumina Infinium DNA Methylation Beadchips (27K vs 450K vs EPIC vs EPICv2)! The field appreciates you, Wanding Zhou! biorxiv.org/cgi/content/sh…

🚀Excited to share our latest preprint on the Methylation Screening Array (MSA) design to facilitate human EWAS discoveries. MSA leverages previous EWAS, bulk, single-cell WGBS data, and technologies for ultra-high throughput profiling. Checkout details: biorxiv.org/cgi/content/sh…

Check out our discussion with Tzachi Reizel on the causality of replicative epimutations in aging, cancer, & epigenetic clocks. 👆

In a new pre-print with Wanding Zhou (Wanding Zhou) and Ivan Zhao, Mike Sheehan (Michael Sheehan) and I asked how rates of age-associated epigenetic change compare between lab mice living under standard lab conditions and those living in our semi-natural outdoor enclosures.

Wonderful thread by amazing postdoc Matthew Zipple 🇺🇦 on a new collaboration with Wanding Zhou and his lab now out as a preprint on bioRxiv 🐁 🐭 🧬 Rewilding lab mice changes the epigenetic patterns associated with aging.

Check out our preprint and great summary by Matthew Zipple 🇺🇦 and Mike Sheehan (Michael Sheehan). In brief, we reported differential epigenetic aging in mice living in a more natural field enclosure rich in physical and social interactions, to simulate the wild environment. 👇

Excited with to share our new deep single-cell whole genome bisulfite sequencing technique with Hui Shen, along with some truly innovative DNA methylation analyses by lead author and talented MD/PhD student, Nathan Spix biorxiv.org/content/10.110…

Best team ever! Hui Shen from Van Andel Institute (VAI) , Chuck Drescher from @Fredhut, and Jarrod Marto from Dana-Farber. Surprising results on impact of BRCA mutations on the Fallopian tubes. BasserBRCA Penn Medicine CSO Penn Center for Genome Integrity nature.com/articles/s4146…

Out now in Aging Cell, we show that mice living under ecologically realistic conditions show faster rates of epigenetic aging in the liver as compared to genetically identical animals in the lab: onlinelibrary.wiley.com/doi/10.1111/ac… With Wanding Zhou and Michael Sheehan

DNA methylation goes spatial! Introducing Spatial-DMT: a technology that co-profiles DNA methylation and transcriptome in the same tissue section. A fantastic collaboration with Wanding Zhou lab. Kudos to Chin Nien Lee Chin Nien Lee and Hongxiang Fu! biorxiv.org/content/10.110…

Our paper on deep single-cell DNA methylation analysis is out in Nature Communications rdcu.be/evfJm. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.