🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

💫NEW: Hervé, Scelfo et al. show that #chromosome missegregation induces #mTORC2 - & ATR-mediated p53 activation via a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension. nature.com/articles/s4155…

🧬⛓️‍ Our latest preprint examines the fate of collapsed forks in vertebrates 🐸 and our colleagues in @heathmurraylab asked similar questions in bacteria 🦠 Together our studies indicate that the response to fork collapse is shaped by evolution (see🧵) biorxiv.org/content/10.110…

Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors rdcu.be/edRwF. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.

Our review epub CSHLPress. Great ride led by Luis Batista WashU Medicine Division of Hematology & by @CEI-FCCC Fox Chase Cancer Center contributing to an understanding of telomerase RNP - the immortality enzyme hijacked by 85% cancers and the untapped "fountain of youth" for aging diseases.

We designed “Rainbow Nucleus” to reveal the secret relationships among five major nuclear membrane-less organelles using live-cell imaging. A lot is unknown: what mediates these interactions? What are the functions? biorxiv.org/content/10.110…

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank Chaolin Zhang Hachung Chung at Columbia University Lena Steckelberg More to come nature.com/articles/s4158…

Delighted to share that the results of my main postdoc project are now published in nature 🔗 doi.org/10.1038/s41586…

Sharing our latest work University of Zurich tracking DNA damage inheritance by Live+QIBC nature.com/articles/s4158…. Huge congrats to Andreas Panagopoulos, M. Stout and all co-authors for this tour de force! Beautifully summarized by Sarah Aitken and E. Reilly Nature News & Views nature.com/articles/d4158….

In this study, Seppa et al. dissect the mechanisms by which DNA nucleases resect single-strand DNA gaps and regulate repair kinetics, with critical implications for BRCA1-deficiency and PARP inhibitor sensitivity. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352421

Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested, closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationIni…

🧬New from crystal structures from our lab in EMBO J! We reveal how the FANCM enzyme, an emerging therapeutic target it cancer, has evolved to specifically recognise branched DNA and activate the Fanconi anaemia pathway of DNA repair. doi.org/10.1038/s44318… 🧵👇

Wondering what is a nucleoporin doing at repair sites? Check it out in our most recent paper in Molecular Cell! dlvr.it/TLBMbH

Happy to share our updated opinion on the physiological roles of BRCA1 in this new review: authors.elsevier.com/a/1lDKu3QxxSyl…

In our latest paper, we uncover condensin II as a novel BLM interactor critical for genome stability in S phase. Condensin II contributes to BLM localization at active forks and undergoes a transient structural change in S phase.nature.com/articles/s4200…

Endogenous tagging of BLM and PICH reveal their dynamic localization and functions throughout the cell cycle. New preprint: Mitotic BLM functions are required to maintain genomic stability biorxiv.org/content/10.110…

WE ARE HIRING: Postdoc Positions! Join us at UPenn in vibrant Philly, cutting-edge science, great city, amazing team. Please share and let's get in touch!

Why does cytarabine hit the brain so hard? 🧠It causes DSBs, especially in Purkinje cells! Meanwhile, Gemcitabine plays much nicer! Check out our paper in Nature today! Huge thanks to my mentor André Nussenzweig andre nussenzweig lab and all my amazing colleagues! nature.com/articles/s4158…

Online Now: TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling dlvr.it/TLjbyj