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John Lukens Thanks John! Against our original hypothesis, genetic deletion of miR-155 enhances MGnD response via IFNg signalling associated with beneficial outcome in AD mice. Congratulations to Zhuoran Yin and shawn Herron. This was a collaborative effort with Tsuneya Ikezu lab.

Our work “Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease” is online! #NatureNeuroscience Congratulations ButovskyLab Oleg Butovsky Tsuneya Ikezu Shawn Herron nature.com/articles/s4159…

Identification of a protective #microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of #Alzheimer’s disease New from ButovskyLab Oleg Butovsky Tsuneya Ikezu, @zhuoran_yin shawn _herr57997 et al. nature.com/articles/s4159…

Milica Margeta, MD, PhD, together with her colleagues from across Mass General Brigham, demonstrates how collaboration across the hospital system can lead to innovative treatments for patients in The New York Times. #VisionResearchMonth

1-APOE4 puts breaks on microglia in Alzheimer's disease rdcu.be/dmYbK Our new work featured in @NatureImmunology shows that APOE4 impairs microglia from acquiring the MGnD phenotype by inducing TGFβ-mediated checkpoints including TIM3 and INPP5D in AD brains

2-deletion of these checkpoints restores microglial activation to harness astrocytes to fight pathology in AD mice.   #NatureImmunology Congratulations ButovskyLab, Oleg Butovsky, Zhuoran Yin, NetaRosezweig on the exciting work #microglia, #AlzheimersDisease, #neuroinflammation

OBS #Neuroimmunology Seminar PAPER HIGHLIGHT "#APOE4 impairs the #microglial response in #Alzheimer’s disease by inducing #TGFβ-mediated checkpoints" (Nature Immunology) Co-first authors Zhuoran Yin NetaRosezweig ButovskyLab 📆 Thu, Nov 30, 12 pm ET ✍️ us02web.zoom.us/meeting/regist…

OBS #Neuroimmunology Seminar 📆 Thu, Nov 30, 9 am PT/12 pm ET 🎙️ Zhuoran Yin ButovskyLab Oleg Butovsky "#APOE4 impairs the #microglial response in #Alzheimer’s disease by inducing #TGFβ-mediated checkpoints" (Nature Immunology 2023) ✍️ us02web.zoom.us/meeting/regist… #Openscience

The new issue of #ScienceTranslationalMedicine is out now! Inhaled xenon gas shows promise against hallmarks of Alzheimer's disease in mice, a gene therapy combats gut symptoms in models of pediatric neurodegenerative disorders, and more. scim.ag/3PBbIAj

With ButovskyLab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimers disease. Deletion of TIM-3 in microglia enhances phagocytic clearance of toxic amyloid beta. nature.com/articles/s4158…

Targeted deletion of TIM-3 in microglia enhances phagocytosis, shifts them toward a protective state, and improves cognition in an AD mouse model. Kuchroo Lab Oleg Butovsky Ayshwarya Subramanian Zhuoran Yin Ahad Khalilnezhad Gene Lay Institute of Immunology & Inflammation #Microglia #TIM3 📄 nature.com/articles/s4158…

Thrilled to have collaborated with the amazing Kuchroo Lab! We uncovered that silencing of a GWAS-AD TIM-3 in an #Alzheimers model by supercharging microglial clearance of toxic amyloid beta. A big step forward for neuroimmunology and translational research!