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What is happening in the pallido-subthalamic circuit during DBS?! We had a unique opportunity to stim/record from both structures in a patient with dystonia to better understand the origins of ERNA... Brain Stimulation dx.doi.org/10.1016/j.brs.… 1/3

Can optogenetics be used to control activity in human brain tissue? Check out our new publication in Nature Neuroscience (nature.com/articles/s4159…) Here's a breakdown 🧵 1/14

New unit paper published in Movement Disorders Journal by C Wiest, T Simpson, et al. from the Tan group, shows that stimulation-evoked resonant neural activity (ERNA) in the subthalamic nucleus (STN) is modulated by sleep. mrcbndu.ox.ac.uk/publications/s… Nuffield Department of Clinical Neurosciences University of Oxford

One step closer to bringing optogenetics to people for precision neuromodulation. Such an incredible technology but the translational gap has always been a challenging task. Love to see this technology grow and evolve!

NREM sleep improves behavioral performance by desynchronizing cortical circuits | Science science.org/doi/10.1126/sc…

Can DBS improve memory in PD? ✅18 Patients randomized (1:1 ratio) to either 4 Hz or 130 Hz DBS during early NREM sleep ✅4 Hz DBS improved overnight memory retention ✅Stronger memory improvement correlated with ⬆️ cortical low frequency activity …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

Huge thanks to all my fantastic co-authers, in particular, Hayriye Cagnan and Huiling Tan, for their great mentoring on this!

Although we don’t want this fight now, if we have to have it we will. We have all the funders/unis/institutes on our side. Elife papers will be treated just the same as before. And maybe we can collectively put a dent in Clarivate’s business model.

Looking forward to our very own Huiling Tan's talk at the Brain Conference 2025! MRC BNDU, Oxford Nuffield Department of Clinical Neurosciences University of Oxford

Sleep spindles, seen in NREM sleep, are thought to be involved in memory consolidation. Study shows a higher spindle density during nights with STN DBS ON vs. OFF. Recent study by @segroppa showed that 4 Hz DBS improved overnight memory retention in PD. sciencedirect.com/science/articl…

hhh true

Check out this amazing open-source tool for markerless video kinematics - VisionMD by Acevedo and Guarin from UF College of Health & Human Performance. Excited for precision quantification of movement disorders! nature.com/articles/s4153… See the tool here VisionMD.ai

So excited to share that DeepPrep is now online in Nature Methods! 🚀 It’s 10× faster than the SOTA pipeline and more robust in handling clinical cases. We’ve just released v25.1.0 with a concise GUI and support for both Win and Linux. Give it a try! 📷 shorturl.at/0pB4H

Why do tics occur? The answer remains mysterious however after two plus decades of research and several NIH grants we are inching closer and this is helping us to develop next generation neuromodulation as a treatment. Had a great conversation on Mathieu Norry's Irish based

Super interesting!

🚨 Calling all neurosurgeons & neuroscientists! Abstract submissions for AASSFN 2025 (May 22-23, Beijing) are now OPEN! Showcase your research & join leaders in functional neurosurgery. Submit here 👉 aassfn2025.com.cn/abstractDeadli… approaching—don’t miss out! #AASSFN2025 #Neurosurgery

AASSFN 2025 (May 22-23, Beijing)

🚨 Calling all neurosurgeons & neuroscientists! aassfn2025.com.cn AASSFN 2025, let' meet in May 22-23, Beijing. #AASSFN2025 #Neurosurgery

If someone offers to sell you stem cells to treat or cure your Parkinson's, do you know what questions to ask and what documents to collect? Two new studies in Nature this week have reignited the topic of stem cells as a treatment for Parkinson's. Spoiler alert: always ask for