🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

My lab athavalegroup.org is looking for postdoc candidates eligible for the 2024-25 Fulbright Fellowship usief.org.in/Fulbright-Nehr… UCLA, we have exciting projects in organic chemistry, biocatalysis, protein engineering and synthetic biology. Eager to hear from you!

Biocatalysts make chemical industry more sustainable but engineering enzymes is too slow! Check out our preprint Hollfelder Lab where we show how microfluidics & AI can help: We rapidly sequence-function profile an IRED in microdroplets and use AI to accelerate its engineering⚡️

After losing my account for over a year, I finally got it back with the help of Twitter Support👍 Here to share a review that my students and I wrote during this period on biocatalytic C–N bond-forming reactions: sciencedirect.com/science/articl…

Our paper is finally online! Check out how enzymes could distinguish Me-Et substitutes to forge alpha-tertiary amines enantioselectively!

My primary PhD project with Frances Arnold at Caltech is out now in Nature Chemical Biology! Here we show that the β-subunit of tryptophan synthase (TrpB) is a latent *tyrosine* synthase (TyrS), capable of regioselective and irreversible alkylation of phenols to tyrosines. Read more below:

Our first pre-print is live! We harness the power of voltage-controlled electrolysis by developing Shono-type amination. Electroanalytical tools guide selective oxidation of substrate over nucleophile, enabling predictable and modular C–N bond formation. go.shr.lc/3Kx9u2n

We are pleased to share our most recent work on chiral enone synthesis through enzymatic desaturation and reduction rdcu.be/dMuJ0! Many thanks to all coauthors, especially Marc Garcia-Borràs and Carla Calvó-Tusell 🤝stay tuned for more works from our group!

Prof. Keary Engle of the Engle Lab is the new Dean of Graduate and Postdoctoral Studies at Scripps Research, leading the Scripps Research Graduate Program. An alumnus, Engle brings personal experience and is committed to mentoring future researchers. More: ow.ly/FcHR50Su8l2

Really proud of this new work! #Enzymes never cease to amaze me. #directedevolution #biocatalysis

What an honor to be chosen for the Priestley Medal. #Enzymes are the best chemists, of course, but the Priestley medalists are no slouches...and include many of my colleagues Caltech Chemistry & Chemical Engineering. Thank you!

I am excited to share our latest discovery which is out now in J. Am. Chem. Soc.! This study uncovers how engineered hemoproteins can leverage biological nitrogen cycle intermediates for enzymatic C–H amination, opening new paths towards sustainable synthesis. pubs.acs.org/doi/10.1021/ja…

Check out our recent paper on an enantioselective H atom transfer reaction catalyzed by an artificial metalloenzyme. A big thank you to Dongping and Xiang for this inspiring piece of work. nature.com/articles/s4155…

Excited to share our preprint on Active Learning-Assisted Directed Evolution (ALDE)! We present a practical workflow that leverages uncertainty quantification to efficiently navigate protein fitness landscapes. 🧵(1/6) Paper: biorxiv.org/content/10.110… Code: github.com/jsunn-y/ALDE

Happy to share that our work "A combinatorially complete epistatic fitness landscape in an enzyme active site" by myself, Patrick Almhjell, Dr. Ella Watkins-Dulaney, Grace Liu, Nick Porter, Jason Yang, and Frances Arnold is now out in PNASNews! (1/15) pnas.org/doi/10.1073/pn…

So happy to see Peng lab is open! Join Peng lab if you are interested in the interdisciplinary fields of machine learning, data science and material science!

My team at Deepmind (protein design) is hiring an experimentalist with enzyme expertise. Please RT and/or apply! I'm happy to answer any questions as well. boards.greenhouse.io/deepmind/jobs/…

Note: most MIT professors I know are honest and morally upright

I am thrilled to share our recent Nature Catalysis cover-featured paper on engineering nonheme iron enzymes for metallophotoredox catalysis, enabling decarboxylative C-N₃ and C-SCN bond formation nature.com/articles/s4192…. This work was pioneered and led by graduate student Jinyan

Due to the Eaton Fire in Altadena and strong winds in the area, Caltech’s campus in Pasadena will be closed for all nonessential operations on Wednesday, January 8. For more information, visit Caltech's Emergency Updates page. caltech.edu/emergency

Happy to share that our work on Active Learning-Assisted Directed Evolution is now published in Nature Communications! We show that it's an effective and broadly applicable method to accelerate protein engineering with machine learning. Paper: nature.com/articles/s4146…