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Checkout our latest review led by J Roney and X Cheng. We overview how endolysosomal trafficking and functionality maintain axonostasis and become disrupted in axonal degeneration. We are recruiting postdocs.(research.ninds.nih.gov/sheng-lab). Please R/T. rupress.org/jcb/article/22…

Very excited we have a new preprint out! This was a joint effort between Koslover Group UCSD @SaurabhMogre Erika Holzbaur-Howland and I to computationally model autophagosomal maturation in axons biorxiv.org/content/10.110…

Schematic diagram showing motor–adaptor complexes mediating kinesin and dynein motor recruitment to LE/LY membranes for MT-based transport along axons. From a review by Roney, Cheng, and Zu-Hang Sheng @NINDSnews. bit.ly/3Lnqo2O #Neuroscience #Trafficking

Check out our review in Neuron, contributed by Xiutang Cheng and Ning Huang. We overview recent advances in how neurons maintain a healthy pool of axonal mitochondria and potential strategies that target bioenergetic restoration within axons. authors.elsevier.com/a/1ewBi3BtfH1X…

Join us this week for two great #nCyto talks by Sandhya Koushika and Zu-Hang Sheng! Thursday, May 5. Register at bit.ly/35ZV1Ly

I am grateful to be one of the highlights in the NINDS Director’s post on the celebration of Asian American, Native Hawaiian, and Pacific Islander Heritage Month 2022.

Happy to share a featured review out in the new issue Neuron on Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration. Congrats to Xiutang Cheng, @nigg_huan, and the Sheng Lab: research.ninds.nih.gov/sheng-lab. cell.com/neuron/fulltex…

Thanks to a great collaborative effort with Neuron editors Neuron, and Xiutang Cheng, Ning Huang. The maintenance of axonal mitochondria & energy metabolism is one of the most interesting topics to power neuronal survival, function, & regeneration.

Congratulations to Sunan Sunan Li for winning NINDS Image Contest.

We have liftoff! Great overviews of the official launch of the iPSC Neurodegenerative Disease Initiative (iNDI). Large-scale, NIH-funded resource of genetically-engineered isogenic iPSC lines harboring neurodegeneration-related mutations. nia.nih.gov/news/new-web-p…

...including an intriguing role for Syntaphilin in reducing Split-Miro-dependent fly hyperactivity Zu-Hang Sheng. The use of the LOV2/Zdk1 module was inspired by the beautiful work of Jeffrey van Haren @WittmannTorsten and colleagues on EB1. 9/10

.Zu-Hang Sheng et al review how axonal endolysosomal trafficking, distribution, and lysosomal functionality support neuronal health & become disrupted in several neurodegenerative diseases bit.ly/3Lnqo2O From our Cellular Neurobiology 2022: bit.ly/3NQFD5Y #SfN22

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport nature.com/articles/s4146…

Delighted to share our review led by Sunan Li and invited by co-editors Inna Slutsky and RH Swerdlow. We overview recent advances in how oligodendrocytes support axonal energy metabolism in health and neurological disorders. authors.elsevier.com/a/1gsm73Q9h2Ee…

Thrilled to share that #NIHOxCam scholar Aditi Kulkarni recently passed her First Year Report!! Aditi is co-mentored by Zu-Hang Sheng in the NINDS and Andras Lakatos at Cambridge University. Way to go Aditi 🎉

I am shocked and saddened to learn of the passing of Bill Catterall, my postdoc mentor and a pioneer and giant in ion channel research. It is a great loss for science.

Really Fun visiting UNC Chapel Hill and meeting faculty and graduate students in Department of Pharmacology. Many thanks to Juan Song Juan Song for hosting. It was great hearing about all of exciting research form the Song Lab and others!

Delighted to share our review. Congrats to Gui-Jing Xiong! Thank JCB editor @andrea_marat for handling this review so well, and the reviewers who provided constructive comments. Very happy to publish with Journal of Cell Biology.

thrilled to share our latest review discussing presynaptic perspectives of neurodevelopmental disorders by focusing on impaired axonal transport and disturbed assembly and maintenance of presynapses. hubs.la/Q02rGTT70

We are delighted that our recent review has been included in the JCB Cellular Neurobiology 2024 Special Collection.