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New Paper Alert: Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR doi.org/10.1038/s41467… Congratulations @McGovernLab & Jake!

#Cover: PLK1 regulates NLRP3 inflammasome activation by controlling microtubule organization: buff.ly/3MmUEgj Xuan Li_Lab Marta Baldrighi Xiaohui Zhao Emily 🏳️‍🌈👩‍🔬 Murray Clarke Lab Guillermo de Cárcer @m_malumbres Ziad Mallat #CellBiology #Immunology

Very happy to share our article showing that T follicular helper cells protect from atherosclerosis promoting IgM secretion by MZB cells! It was not an easy path!! I can’t be happier! Thank you#CVR Mallat_Lab Christoph Binder McNamara Lab (UVA) Jason Tarkin and all! academic.oup.com/cardiovascres/…

Super news that Meritxell’s work is being recognised, be sure to catch her at the BAS/BSCR 2024 meeting! Congrats Meri!!!!

New publication doi.org/10.1093/cvr/cv…

New collaborative work with Jason Tarkin lab linking immune dysfunction and cardiac MRI abnormalities in people with unexplained cardiovascular symptoms after COVID-19 infection. Thanx to CambridgeCardio pump-priming award and British Heart Foundation eur03.safelinks.protection.outlook.com/?url=https%3A%…

Check our paper in nature nature.com/articles/s4158… This is a huge collaborative work combining great basic and clinical science, with important implications for the prevention of atherosclerotic cardiovascular disease. Thanks to all our collaborators and funders!

Well done Jane Goodall & Minoru! Blockade of GDF15 would be a new therapeutic option to limit cardiac cachexia and improve clinical outcomes in patients with severe systolic heart failure. VPD Heart & Lung Research Institute CambridgeCardio British Heart Foundation academic.oup.com/cardiovascres/…

Thrilled to share the first paper from my group, published in Nature Cardiovascular Research! Led by Ayden Case, with special thanks to Ziad Mallat and Mallat_Lab 🙏 🔖Low-dose IL-2 induces clonal expansion of BACH2-repressed effector Tregs after acute coronary syndrome.🔖 nature.com/articles/s4416…

Translating T cell targeted therapies to treat cardiovascular disease. Insights from the LILACS trial. Cambridge University CambridgeCardio British Heart Foundation