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Sedentary chromosomal integrons (SCIs) are biobanks of anti-phage defence systems! In a huge collaboration with the Didier Mazel lab, we showed that these flexible genetic platforms encode known defences and further discovered 16 new systems. A thread (1/n) doi.org/10.1101/2024.0…

MDMLab Baptiste Darracq @epcrocha Loot Céline Didier Mazel @FredoLeRoux David Bikard Aude Bernheim weronika slesak Kevin Debatisse Finally, have also a look at a related study led by Nicolas Kieffer, PhD from Jose A Escudero's group, released back-to-back doi.org/10.1101/2024.0…

Our paper about integrons and their fascinating content is on biorXiv🤩Go check out Eloi's thread for a sneak peek of what these big fellas are capable of !

Check out our latest preprint! This work was lead by Nicolas Kieffer, PhD with the support of the whole MBA lab, especially Alberto.HCA . If you are interested in the intersection between #Phage resistance and #AMR pull the thread! 🧵 biorxiv.org/content/10.110…

Let's not underestimate Integrons this time. They can bring cassettes from Chromosomal Integrons in many genomes. And you know what? These are packed with defence systems too!!! Check the back-to-back work from Didier Mazel Loot Céline Eloi Littner @epcrocha biorxiv.org/content/10.110…

Happy to share our work in Nature Microbiology. Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. If you're interested in #Antiphage #T6SS #Vibrio #MGE then this is for you. 🧵1/15 rdcu.be/dXMwQ nature.com/articles/s4156…

I am in awe of the near-infinite complexity of Earth's lifeforms. Here Vanya Zheludev discovers a new and widespread class of viroid-like entities, #Obelisks, hidden in our own bodies. One for the textbooks! Cell 🔗: sciencedirect.com/science/articl… #viroid #virology #genomics

White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the Didier Mazel lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…