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Our paper on engineering uracil-N-glycosylase using protein language model ESM is now published in Molecular Cell. Xibin Zhou Would love to know if replacing ESM with our Saprot (biorxiv.org/content/10.110…) would result in better performance. sciencedirect.com/science/articl…

Is DNA all you need? Introducing Evo, a long context 7B foundation model for biology Evo has SOTA *zero-shot* prediction across DNA, RNA, and protein modalities Evo can generate DNA, RNA+proteins & make CRISPR-Cas systems for first time blog …n-model-tool-arc-institute.vercel.app/news/blog/evo

Despite the mixed feelings about Google's latest Gemma model, we're big fans! Google AI Why? Coz we found it pairs incredibly well with our SelfExtend 🤣🤣🤣 - like, perfectly! With Self-Extend, no fine-tuning needed, we effortlessly expanded Gemma's window from 8k to 90k+! On

Excited to see how PTM-Mamba opens the door for PTM-aware structure prediction and protein design.

Today, we're announcing Claude 3, our next generation of AI models. The three state-of-the-art models—Claude 3 Opus, Claude 3 Sonnet, and Claude 3 Haiku—set new industry benchmarks across reasoning, math, coding, multilingual understanding, and vision.

Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬 Here’s how we built it with Isomorphic Labs and what it means for biology. 🧵 dpmd.ai/3URDiNo

Now everyone customize/share protein language models for their custom task/dataset via Colaboratory 🤓 Paper: biorxiv.org/content/10.110… Colab: colab.research.google.com/drive/1nxYBed3… Credit: Jin Su, Zhikai Li, Chenchen Han, Yuyang Zhou, Junjie Shan, Xibin Zhou, Dacheng Ma, fajie yuan

Introducing ProTrek, a 3-modal PLM for protein seq, struc, and func: ✨ Trained on 40M protein-text pairs, 100x larger than ProteinCLIP, ProtST, ProteinCLAP 🚀 30x/60x better accuracy than ProtST, ProteinCLAP ⚡ 100x faster than Foldseek, MMseq2 for similar function searches

Recruited 12 bio students, no coding exp, to use ColabSaprot for re-training, zero-shot mutation, & protein design. They matched AI experts w/o hyper-parameter tuning! With SaprotHub, any biologist can train protein models! Sergey Ovchinnikov Jin Su biorxiv.org/content/10.110…

The found Cas13an (UniProt ID: A0A7C5SD50) was annotated as an uncharacterized protein in the database. We used ProTrek to annotate it and the results were related to CRISPR, showing ProTrek is capable of indentifying unknown proteins.

Used SaprotHub to predict mutations for eTDG, a uracil-N-glycosylase variant. 🧬 Lab results: 17 out of top 20 mutations had higher T-to-G editing efficiency than wild type (marked as red), with 3 showing nearly 2x improvement! 🚀

🧬✨Excited to share our online demo " Natural language → De Novo Protein design" Live demo: http://113.45.254.183:8888/ The demo version Pinal is 1.2B.🔬 You try very detailed textual prompt up to 500 words. biorxiv.org/content/10.110…