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A new viewpoint from Rosen and Kajimura Journal of Clinical Investigation BIDMC "For now, however, we believe that the community should approach the notion that inflammation is the driver of #insulin resistance in humans as a hypothesis, rather than a proven fact" jci.org/articles/view/…?

🚨After 8y and many dead ends- we are excited to clarify how "stable" adipocyte lipolysis is potently activated independent of catecholaminergic signals while being restrained by glucose and insulin. RT and feedback welcome as we work from preprint to pub! biorxiv.org/content/10.110…

Happy to share our collaborative review in Nature Reviews Cardiology on #lysosome #immunology #metabolism & #atherosclerosis. Fun working with European colleagues Fabrizia Bonacina Giuseppe Danilo Norata Yvancharvet Laurent. All started when met at Athero 2023 Gordon Research Conferences in Barcelona! nature.com/articles/s4156…

After one year of publication gaps (post-tenure procrastination syndrome😂), we finally got two new #peroxisome papers out this year. 1. Peroxisomal import stress activates integrated stress response and inhibits ribosome biogenesis. academic.oup.com/pnasnexus/adva…

New paper by Pedro Latorre Muro published in Cell! We combined thermoregulatory physiology, structural and computational approaches to determine the mechanisms of electron transfer and structural basis of respiratory complex adaptation to cold temperatures.

A comprehensive multiomics analysis in Science Translational Medicine identifies three major molecular subtypes of NAFLD in two cohorts of patients in China, shows new research that could inform efforts to predict and intervene in the risk of progressing to cirrhosis or liver cancer. 📄:

If you're interested in #glutamine & glutamine-glutamate ratio in #CVD #atherosclerosis, check out our News&Views piece in Nature Cardiovascular Research led by postdoc @liu_ziyang37822 reviewing the field in the context of excellent work by lab of Yvancharvet Laurent in same issue. nature.com/articles/s4416…

In a perspective on brown adipose tissue (BAT), Dr. Aaron Cypess (Aaron Cypess) and a team of international investigators discuss six debated topics related to BAT, proposing experiments to resolve each one and advance the field cell.com/cell-metabolis… Cell Metabolism

Our latest pub is out in Diabetes, a research journal of the ADA 🧪 🎉We conducted a comprehensive evaluation of body composition, metabolic function and adipose tissue remodeling in women with #lipedema. Congrats to all authors 👏👏and thanks to Lipedema Foundation diabetesjournals.org/diabetes/artic…

Really glad to see this published. Great work Andrew J. Lutkewitte!

Great to see our #protein #leucine #CVD work highlighted by Nature Metabolism as top most profiled paper in 2024! Happy new year & hopefully we bring you exciting data on #plantprotein soon! Shout out to Xiangyu Zhang Babak Razani, MD, PhD Laboratory & PittDeptofMed WashU Medicine Department of Medicine, other collaborators 🤝

New Millman lab publication out in Advanced Science using genetically engineered brain organoids to model glioblastoma (GBM). Excited to collaborate with Albert H. Kim to extend our stem cell expertise to cancer. Congrats 1st author Matthew Ishahak advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

We are hiring! After the publication of our last paper, our lab has openings for #postdoc fellows in projects looking at the interactions between tumor metabolism and immunology. Direct inquiries to [email protected]. Please RT! (1/2)

Is dietary #protein and #mTOR good for skeletal muscle health or not? At least for #sarcopenia in elderly it is paradoxically harmful and enhancing #BCAA catabolism is protective. Interesting work in Nature Aging by lab of Prof. Tao Li Sichuan University. nature.com/articles/s4358…

Wow, what a resource! Adiposetissue.org is full of curated bioinformatics datasets developed by Helmholtz Munich | @HelmholtzMunich Karolinska Institutet Steno Diabetes Center Copenhagen. Thank you to our European colleagues! 🤝 Also detailed in Cell Metabolism article this week. cell.com/cell-metabolis…

Lysosomal Acid #Lipase (Lipa/LAL) is upregulated in #AdiposeTissue during #fasting, cold exposure, and even #obesity. When we ablate #adipocyte Lipa/LAL, mice cannot undergo full #lipolysis with difficulty maintaining body temperature in cold. On #highfat diet, they become obese.

Please check out the latest paper from the Babak Razani, MD, PhD Laboratory revealing that adipocytes don’t just break down fat the usual way: lysosomal lipolysis steps in during fasting & cold exposure to meet the energy demands. Congrats to the entire team! jci.org/articles/view/…

Proud to share our work online today in Nature Metabolism! My first ever student and first author of the paper Dylan Duerre summarizes here perfectly! Big thanks to our colleagues UW–Madison, UW School of Medicine and Public Health and uofutah for this collaboration! #brownfat #Metabolism

Thrilled to have our story on the regulation of lysosomal lipids out in Cell Metabolism! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure HHMI UW–Madison Biochem

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science science.org/doi/10.1126/sc…